Yang Wenjie, Yang Shikun, Zhang Feng, Cheng Feng, Wang Xuehao, Rao Jianhua
Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation, Nanjing 210029, China.
Ann Transl Med. 2020 Mar;8(6):399. doi: 10.21037/atm.2020.02.11.
A large number of immune cells are present in the tumour microenvironment (TME), of which, tumour-associated macrophages (TAMs) are among the most important and highly infiltrated cells, and mainly include the M1 type classically activated and M2 type alternatively activated TAMs. Both cell types are known to play an important role in tumour initiation and proliferation. It has recently been confirmed that the TAMs in tumours tend to be dominated by the M2 type. However, the precise mechanism underlying TAM recruitment and polarization in the immune microenvironment remains to be elucidated. The Hippo-Yes-associated protein (YAP) signalling pathway is one of the most extensively discussed mechanism for the regulation of tumour proliferation, migration, angiogenesis, and invasion in recent years. To date, several studies have revealed that YAP is involved in the interrelating interactions between tumour and immune cells, particularly the TAMs. In this review, we have summarized the mechanism by which the YAP regulates the activity of TAMs and its impact on the TME.
肿瘤微环境（TME）中存在大量免疫细胞，其中肿瘤相关巨噬细胞（TAM）是最重要且浸润程度最高的细胞之一，主要包括经典激活的M1型和交替激活的M2型TAM。已知这两种细胞类型在肿瘤发生和增殖中均发挥重要作用。最近已证实肿瘤中的TAM倾向于以M2型为主。然而，免疫微环境中TAM募集和极化的精确机制仍有待阐明。Hippo-Yes相关蛋白（YAP）信号通路是近年来关于肿瘤增殖、迁移、血管生成和侵袭调控的讨论最为广泛的机制之一。迄今为止，多项研究表明YAP参与肿瘤与免疫细胞之间的相互作用，尤其是与TAM的相互作用。在本综述中，我们总结了YAP调节TAM活性的机制及其对肿瘤微环境的影响。
