感染嗜肺军团菌血清型1、6和10的患者中抗军团菌抗体的特征
Characteristics of anti-Legionella antibodies in patients infected with Legionella pneumophila serogroups 1, 6, and 10.
作者信息
van Zwet T L, Meenhorst P L, Leijh P C, Daha M R, van Furth R
机构信息
Department of Infectious Diseases, University Hospital, Leiden, The Netherlands.
出版信息
J Clin Microbiol. 1988 Nov;26(11):2377-81. doi: 10.1128/jcm.26.11.2377-2381.1988.
Nosocomial infections with Legionella pneumophila serogroups 1 and 10 in the Leiden University Hospital and infections with L. pneumophila serogroup 6 in neighboring hospitals gave us an opportunity to study the development of opsonizing antibodies against L. pneumophila serogroups 1, 6, and 10 in the serum of 13 patients. Seven of these patients were infected with L. pneumophila serogroup 1, two were infected with serogroup 6, and four were infected with serogroup 10. The opsonic cross-reactivity of antibodies against these serogroups of L. pneumophila and complement involvement in opsonization were also investigated. Convalescent-phase sera from patients infected with L. pneumophila serogroup 1 or 6 were able to promote ingestion of these serogroups by polymorphonuclear leukocytes, whereas ingestion of L. pneumophila serogroup 10 was enhanced only in the presence of convalescent-phase sera from patients infected with this serogroup. Opsonization of L. pneumophila serogroups 1, 6, and 10 was complement dependent.
莱顿大学医学中心发生的嗜肺军团菌血清型1和10引起的医院感染，以及附近医院发生的嗜肺军团菌血清型6引起的感染，为我们提供了一个机会，来研究13例患者血清中针对嗜肺军团菌血清型1、6和10的调理抗体的产生情况。其中7例患者感染了嗜肺军团菌血清型1，2例感染了血清型6，4例感染了血清型10。我们还研究了针对这些嗜肺军团菌血清型的抗体的调理交叉反应性以及补体在调理作用中的参与情况。感染嗜肺军团菌血清型1或6的患者恢复期血清能够促进多形核白细胞摄取这些血清型细菌，而只有在感染该血清型的患者恢复期血清存在时，嗜肺军团菌血清型10的摄取才会增强。嗜肺军团菌血清型1、6和10的调理作用依赖补体。
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