Meenhorst P L, Reingold A L, Groothuis D G, Gorman G W, Wilkinson H W, McKinney R M, Feeley J C, Brenner D J, van Furth R
J Infect Dis. 1985 Aug;152(2):356-64. doi: 10.1093/infdis/152.2.356.
Between August 1978 and November 1983, 21 cases of pneumonia caused by Legionella pneumophila occurred in the Leiden University Hospital, mainly among immunocompromised patients. A new serogroup of L. pneumophila, designated serogroup 10 (prototype strain Leiden 1), was isolated from bronchial secretions of four patients, and five patients had serological evidence of infection with this organism. Nine patients had a culture-confirmed infection with L. pneumophila serogroup 1. L. pneumophila serogroups 1 and 10 were also isolated from the hot potable water supply in the building to which 19 of the 21 patients had been admitted. The isolates of L. pneumophila serogroup 1 from patients and the hot potable water were identical in studies with monoclonal antibodies and had the same plasmid profiles. These findings provide further evidence that in our hospital potable water contaminated with L. pneumophila is a source of infection, mainly in immunocompromised patients.
1978年8月至1983年11月期间，莱顿大学医院发生了21例由嗜肺军团菌引起的肺炎病例，主要发生在免疫功能低下的患者中。从4例患者的支气管分泌物中分离出一种新的嗜肺军团菌血清群，命名为血清群10（原型菌株莱顿1），5例患者有感染该菌的血清学证据。9例患者经培养确诊感染嗜肺军团菌血清群1。从21例患者中19例所入住大楼的生活热水供应系统中也分离出了嗜肺军团菌血清群1和10。患者和生活热水中分离出的嗜肺军团菌血清群1在单克隆抗体研究中表现相同，且具有相同的质粒图谱。这些发现进一步证明，在我们医院，被嗜肺军团菌污染的生活用水是感染源，主要感染免疫功能低下的患者。
