lncRNAs 的秘密生活：保守但不保守。
The Secret Life of lncRNAs: Conserved, yet Not Conserved.
机构信息
Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.
Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.
出版信息
Cell. 2020 Apr 30;181(3):512-514. doi: 10.1016/j.cell.2020.04.012.
Guo and colleagues discover a new layer of complexity to the lncRNA evolution where positionally conserved lncRNAs in human ESCs are broadly spliced and exported to the cytoplasm contrary to their mouse counterpart that are predominantly unspliced and nuclear retained. Distinct processing leads to species-specific lncRNA function in pluripotency maintenance.
郭等人发现 lncRNA 进化的一个新层面，即人类胚胎干细胞中位置保守的 lncRNA 广泛剪接并输出到细胞质，而其小鼠对应物则主要是未剪接和核保留。不同的加工导致物种特异性 lncRNA 在多能性维持中的功能。
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