University of Carthage, Environmental Biomonitoring Laboratory (LBE), Faculty of Sciences of Bizerte, Zarzouna 7021, Tunisia; Higher Institute of Biotechnology of Beja, University of Jendouba, PB 382, Habib Bourguiba Avenue, 9000 Beja, Tunisia.
University of Carthage, Environmental Biomonitoring Laboratory (LBE), Faculty of Sciences of Bizerte, Zarzouna 7021, Tunisia.
Pestic Biochem Physiol. 2020 May;165:104463. doi: 10.1016/j.pestbp.2019.09.007. Epub 2019 Oct 30.
Cypermethrin (Cyp) is a kind of pyrethroids compound that is broadly used against different species of insects and pests. Cyp can also elicit a range of neurotoxic, immunotoxic, genotoxic and reproductive toxic effects on various experimental organisms. The aim of this study was to evaluate the protective effects of Hibiscus sabdariffa against the toxicity damage induced by Cyp exposure. The Hibiscus sabdariffa calyxes extract was given to mice (200-500 mg/kg bw). The mice, which were treated with Cyp and Hibiscus sabdariffa, were divided into six groups of six mice each. Groups I, IV and VI were used as control and groups II C control (20 mg/kg body weight)., groups III and V were treated with Hibiscus sabdariffa extract (200 and 500 mg/kg body weight) plus (20 mg/kg body weight) for 21 days Furthermore, HPLC was used to identify the compound fraction. This result showed Cyp -induced biochemical changes in all organs of mice. Cyp caused decreased CAT activity, inhibition of AChE activity and increased the levels of HO and MDA in brain, heart, liver and kidney. Hibiscus sabdariffa exhibited antioxidant effect and significantly attenuated the neurotoxicity of Cyp. Hibiscus sabdariffa exhibits neuroprotective effects and can be an effective and novel alternative approach to reduce the risk caused by pyrethroid compound.
氯菊酯（Cyp）是一种拟除虫菊酯化合物，广泛用于防治不同种类的昆虫和害虫。Cyp 还可以对各种实验生物产生一系列神经毒性、免疫毒性、遗传毒性和生殖毒性作用。本研究旨在评估玫瑰茄对 Cyp 暴露引起的毒性损伤的保护作用。给小鼠给予玫瑰茄花萼提取物（200-500mg/kg bw）。用 Cyp 和玫瑰茄处理的小鼠分为六组，每组 6 只。第 I、IV 和 VI 组用作对照，第 II C 对照组（20mg/kg 体重），第 III 和 V 组用玫瑰茄提取物（200 和 500mg/kg 体重）加（20mg/kg 体重）处理 21 天。此外，还使用 HPLC 鉴定化合物馏分。该结果表明 Cyp 诱导了小鼠所有器官的生化变化。Cyp 导致 CAT 活性降低、AChE 活性抑制以及脑中 HO 和 MDA 水平升高，心脏、肝脏和肾脏。玫瑰茄表现出抗氧化作用，显著减轻 Cyp 的神经毒性。玫瑰茄具有神经保护作用，可作为减少拟除虫菊酯化合物引起的风险的有效且新颖的替代方法。
