基于荧光金属的配合物作为癌症探针。
Fluorescent metal-based complexes as cancer probes.
机构信息
Tumour Microenvironment Group, Division of Cancer and Genetics School of Medicine, Cardiff University, Tenovus Building, Cardiff CF14 4XN, UK.
School of Chemistry, Cardiff University Park Place, CF10 3AT Cardiff, UK.
出版信息
Bioorg Med Chem Lett. 2020 Jul 1;30(13):127219. doi: 10.1016/j.bmcl.2020.127219. Epub 2020 Apr 28.
The ability to track drugs inside of cells and tumours has been highly valuable in cancer research and diagnosis. Metal complexes add attractive features to fluorescent drugs, such as targeting and specificity, solubility and uptake or photophysical properties. This review focuses on the latest fluorescent metal-based complexes, their cellular targets, photophysical properties and possible anticancer effects.
追踪细胞和肿瘤内药物的能力在癌症研究和诊断中具有很高的价值。金属配合物为荧光药物增添了吸引人的特性，例如靶向性和特异性、溶解性和摄取率或光物理性质。本文综述了最新的荧光金属基配合物、它们的细胞靶标、光物理性质和可能的抗癌作用。
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