Departments of Perinatal Health Care, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi 214002, China.
Departments of Child Health Care, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi 214002, China.
Clin Chim Acta. 2020 Aug;507:194-198. doi: 10.1016/j.cca.2020.04.030. Epub 2020 Apr 28.
The etiology of Autoimmune thyroid disease (AITD) in pediatric age is multifactorial and mainly implicated with immune disorder. Previous studies have reported that interleukin-21 (IL-21) and vitamin D play crucial roles in autoimmune diseases. We investigated the correlation between IL and 21 and 25(OH)D and their potential role in the pathogenesis of AITD.
Total of 54 primary Graves disease (GD) patients, 36 Hashimato's thyroditis (HT) cases and 30 healthy subjects from The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University from September through November 2017 to 2019. The serum concentrations of IL-21, 25(OH)D, thyroid-stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), antibodies against receptor for TSH (TRAb) and thyroglobulin antibody (TGAb) were determined.
The serum concentration of 25(OH)D was lower while IL-21 was higher in the GD patients and HT patients than in the control patients. Serum 25(OH)D concentration was negatively correlated with TPOAb and TGAb while serum IL-21 concentration was positively correlated with TPOAb, TGAb and TRAb in the HT group. Moreover, the serum concentration of 25(OH)D had a significant negative correlation with serum IL-21 concentration in the HT and GD children before or after treatment. Therefore, we studied the correlation between IL and 21 and 25(OH)D, and infer that they play a role in AITD. Moreover, adding Vitamin D could inhibit the expression concentrations of TPOAb, TGAb and IL-21.
IL-21 and Vitamin D may be involved in the occurrence and development of AITD. Targeting IL-21 and Vitamin D may be a promising therapeutic approach for AITD in the future.
儿科自身免疫性甲状腺疾病（AITD）的病因是多因素的，主要与免疫紊乱有关。先前的研究表明，白细胞介素-21（IL-21）和维生素 D 在自身免疫性疾病中起着至关重要的作用。我们研究了 IL-21 和 25（OH）D 之间的相关性及其在 AITD 发病机制中的潜在作用。
本研究共纳入 2017 年 9 月至 2019 年 11 月南京医科大学附属无锡妇幼保健院的 54 例原发性格雷夫斯病（GD）患者、36 例桥本甲状腺炎（HT）患者和 30 例健康对照者。检测血清 IL-21、25（OH）D、促甲状腺激素（TSH）、甲状腺过氧化物酶抗体（TPOAb）、促甲状腺激素受体抗体（TRAb）和甲状腺球蛋白抗体（TGAb）的浓度。
与对照组相比，GD 患者和 HT 患者的血清 25（OH）D 浓度较低，IL-21 浓度较高。HT 组中，血清 25（OH）D 浓度与 TPOAb 和 TGAb 呈负相关，而血清 IL-21 浓度与 TPOAb、TGAb 和 TRAb 呈正相关。此外，治疗前后 HT 和 GD 患儿血清 25（OH）D 浓度与 IL-21 浓度呈显著负相关。因此，我们研究了 IL-21 和 25（OH）D 之间的相关性，并推断它们在 AITD 中发挥作用。此外，补充维生素 D 可以抑制 TPOAb、TGAb 和 IL-21 的表达浓度。
IL-21 和维生素 D 可能参与了 AITD 的发生和发展。针对 IL-21 和维生素 D 可能是未来 AITD 的一种有前途的治疗方法。
