Fu Gen-Que, Zhang Sheng-Chun, Chen Ge-Gu, Hao Xiang, Bian Jing, Peng Feng
Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, China.
Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, China.
Int J Biol Macromol. 2020 Apr 30;158:244-250. doi: 10.1016/j.ijbiomac.2020.04.235.
Skin care biomaterials from natural compounds are increasingly needed in recent. We demonstrate a simple strategy to fabricate the dialdehyde xylan (DAX) crosslinked hydrogel with skin care potential. The hydrogel mainly consists of dialdehyde xylan, which is used as crosslinker for gelatin (G). Glycerol (Gly) and nicotinamide (NCA) are introduced here for improving the texture, antibacterial property as well as skin care functionality. The in vitro release results demonstrate that NCA can be released smoothly from the xylan-based gel, whereby the xylan-based fabricated gel can be utilized as an ideal matrix gel in skin care with loading and release function. The antibacterial ability is in the following order: Yeast > Bacillus subtilis > Staphylococcus aureus. The cytocompatibility experiments confirm the excellent viability of the gel. These merits demonstrate the fabricated hydrogel as a potential material in skin care.
近年来，对源自天然化合物的皮肤护理生物材料的需求日益增加。我们展示了一种制备具有皮肤护理潜力的二醛木聚糖（DAX）交联水凝胶的简单策略。该水凝胶主要由用作明胶（G）交联剂的二醛木聚糖组成。在此引入甘油（Gly）和烟酰胺（NCA）以改善质地、抗菌性能以及皮肤护理功能。体外释放结果表明，NCA可以从基于木聚糖的凝胶中顺利释放，由此制备的基于木聚糖的凝胶可作为具有负载和释放功能的理想皮肤护理基质凝胶。抗菌能力顺序如下：酵母＞枯草芽孢杆菌＞金黄色葡萄球菌。细胞相容性实验证实了该凝胶具有优异的活力。这些优点表明所制备的水凝胶是一种有潜力的皮肤护理材料。
