Elkihel Abdechakour, Vernisse Charlotte, Ouk Tan-Sothéa, Lucas-Roper Romain, Chaleix Vincent, Sol Vincent
University Limoges, LABCiS, UR 22722, 87000 Limoges, France.
University Limoges, IRCER, UMR CNRS 7315, 87000 Limoges, France.
Gels. 2023 Feb 2;9(2):124. doi: 10.3390/gels9020124.
In the present work, we report on the synthesis of light-triggered antibacterial hydrogels, based on xylan chains covalently bound to meso-tetra(4-carboxyphenyl)porphyrin (TCPP). Not only does TCPP act as a photosensitizer efficient against Gram-positive bacteria, but it also serves as a cross-linking gelator, enabling the simple and easy building of xylan conjugate hydrogels. The hydrogels were characterized by infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM), along with swelling and rheological tests. The antimicrobial activity of the hydrogels was tested under visible light irradiation against two Gram-positive bacterial strains, and . The preliminary results showed an interesting activity on these bacteria, indicating that these hydrogels could be of great potential in the treatment of skin bacterial infections with this species by photodynamic antimicrobial chemotherapy (PACT).
在本研究中，我们报道了基于共价连接到中四（4-羧基苯基）卟啉（TCPP）的木聚糖链合成光触发抗菌水凝胶。TCPP不仅作为一种对革兰氏阳性菌有效的光敏剂，还作为交联胶凝剂，使得木聚糖共轭水凝胶的构建简单易行。通过红外光谱（ATR-FTIR）、扫描电子显微镜（SEM）以及溶胀和流变学测试对水凝胶进行了表征。在可见光照射下测试了水凝胶对两种革兰氏阳性菌株和的抗菌活性。初步结果显示了对这些细菌有趣的活性，表明这些水凝胶通过光动力抗菌化学疗法（PACT）治疗该菌种引起的皮肤细菌感染具有巨大潜力。
