Department of Oral and Maxillofacial Surgery, Identity ENT & Dental Centre, Dehradun (U.K) 248001, India.
Department of ENT, Identity ENT & Dental Centre, Dehradun (U.K), India.
J Stomatol Oral Maxillofac Surg. 2021 Feb;122(1):43-49. doi: 10.1016/j.jormas.2020.04.008. Epub 2020 Apr 29.
This prospective study evaluated the efficacy and healing potential of modified formulation of PRF, commonly known as Advanced PRF (A-PRF) in impacted mandibular third molar extraction sockets.
20 patients with bilateral impacted mandibular third molars were included in this study. Surgical disimpactions were done at 3-4 weeks interval in opposing quadrants of patient. One quadrant received A-PRF while the opposing quadrant in same patient was taken as control. Comparative evaluation was done in terms of pain assessment, analgesics required, swelling, soft tissue healing and trismus on 1st, 3 and 7day follow-up. Comparative assessment of bone healing was also done on 1st, 3and 6month follow-up.
This study involved 12 female and 8 male patients with in age range of 18-35 years. The evaluation of pain, swelling, trismus and soft tissue healing on 3rd postoperative day revealed considerable improvement on A-PRF sites as compared to control sites. The outcomes were found to be statistically significant with p values 0.008, 0.031, 0.0001, 0.05 respectively. Even the analgesic consumption was remarkably less when A-PRF was used (P=0.004). Bone healing evaluation in A-PRF sites on 1st, 3and 6month has shown significantly improved results with P<0.05.
Our study infers that A-PRF has enhanced the healing potential of soft tissue as well as bone in extraction socket. Apart from that it has also shown promising results in relief of immediate postoperative symptoms like pain, swelling and trismus which improves the comfort and acceptability of surgical procedures by patients. Enhanced healing and patient comfort in cost effective manner are the highlighting features of A-PRF.
本前瞻性研究评估了改良富血小板纤维（PRF），即通常所说的高级 PRF（A-PRF）在阻生下颌第三磨牙拔牙窝中的疗效和愈合潜力。
本研究纳入了 20 名双侧阻生下颌第三磨牙患者。在 3-4 周的间隔内，在患者的相对象限中进行手术脱位。一个象限接受 A-PRF 治疗，而同一患者的对侧象限作为对照。在第 1、3 和 7 天随访时，分别从疼痛评估、所需镇痛药、肿胀、软组织愈合和张口受限等方面进行比较评估。在第 1、3 和 6 个月随访时，还进行了骨愈合的比较评估。
本研究涉及 12 名女性和 8 名男性患者，年龄在 18-35 岁之间。术后第 3 天的疼痛、肿胀、张口受限和软组织愈合评估显示，A-PRF 部位的改善明显优于对照组。结果具有统计学意义，p 值分别为 0.008、0.031、0.0001、0.05。当使用 A-PRF 时，镇痛药的消耗量也明显减少（P=0.004）。A-PRF 部位在第 1、3 和 6 个月的骨愈合评估显示，结果有显著改善（P<0.05）。
本研究推断 A-PRF 增强了拔牙窝中软组织和骨的愈合潜力。此外，它在减轻术后即刻症状（如疼痛、肿胀和张口受限）方面也显示出良好的效果，从而提高了患者对手术程序的舒适度和接受度。以经济有效的方式实现愈合和患者舒适是 A-PRF 的突出特点。
