Mathialagan Kalai Selvam Lavanya, M Arun, Lakshmanan Saravanan, Kumar Santhosh P
Oral and Maxillofacial Surgery, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Cureus. 2024 Jan 15;16(1):e52297. doi: 10.7759/cureus.52297. eCollection 2024 Jan.
Introduction Impacted third molar extraction is frequently removed surgically by maxillofacial surgeons, which is mostly associated with postoperative sequelae like pain and swelling. It is essential to minimize the complications and enhance wound healing in the extracted socket of the third molar. Hence, this study aimed to assess the efficiency of advanced platelet-rich fibrin (A-PRF) in wound healing and reducing pain after surgical extraction of the impacted mandibular third molar (IMTM). Materials and methods Thirty healthy patients who have been diagnosed with Pell and Gregory class II IMTM were included in this study. In the study group, which comprises 15 patients, extraction sockets were filled with A-PRF extract. In the control group, no material was placed in the extraction sockets. The pain was assessed preoperative and on the third and seventh postoperative days using a visual analog scale (VAS). Wound healing was assessed on the third and seventh postoperative days using a modified laundry scale. SPSS for Windows was used for data analysis. Categorical data was compared between the groups using the Chi-square test. P-value less than 0.05 was considered as statistically significant. Results The study population's mean age was 25.67 ± 2.4 years. Nineteen patients were male, and 11 patients were female. Differences in mean pain scores between the groups were not statistically significant both on the third postoperative day (p=0.59) and the seventh postoperative day (p=0.33). During the seventh day postoperative day, the study group exhibited better wound healing compared to the control group and the results were statistically significant (p=0.01). Conclusion A-PRF is a simple and effective method of reducing postoperative sequela by promoting wound healing after surgical extraction of IMTM. It has the advantage of less chance of allergic and anaphylactic reactions, unlike their predecessor platelet concentrates.
引言
阻生第三磨牙拔除术通常由颌面外科医生通过手术进行，术后常伴有疼痛和肿胀等后遗症。尽量减少并发症并促进第三磨牙拔牙窝的伤口愈合至关重要。因此，本研究旨在评估高级富血小板纤维蛋白（A-PRF）在阻生下颌第三磨牙（IMTM）手术拔除后促进伤口愈合和减轻疼痛方面的效果。
材料与方法
本研究纳入了30例被诊断为佩尔和格雷戈里II类IMTM的健康患者。在由15名患者组成的研究组中，拔牙窝用A-PRF提取物填充。在对照组中，拔牙窝未放置任何材料。术前以及术后第3天和第7天使用视觉模拟量表（VAS）评估疼痛程度。术后第3天和第7天使用改良的洗衣量表评估伤口愈合情况。使用Windows版SPSS进行数据分析。使用卡方检验比较组间分类数据。P值小于0.05被认为具有统计学意义。
结果
研究人群的平均年龄为25.67±2.4岁。19例为男性，11例为女性。术后第3天（p=0.59）和术后第7天（p=0.33），两组间平均疼痛评分差异均无统计学意义。术后第7天，研究组的伤口愈合情况优于对照组，结果具有统计学意义（p=0.01）。
结论
A-PRF是一种简单有效的方法，可通过促进IMTM手术拔除后的伤口愈合来减少术后后遗症。与之前的血小板浓缩物不同，它具有过敏和过敏反应几率较小的优点。
