SARS-CoV-2 无症状和有症状患者及输血传播风险。
SARS-CoV-2 asymptomatic and symptomatic patients and risk for transfusion transmission.
机构信息
Institute for Virology, Charité University Hospital, Berlin, Germany.
Institute for Medical Virology, University Hospital, Goethe University, Frankfurt, Germany.
出版信息
Transfusion. 2020 Jun;60(6):1119-1122. doi: 10.1111/trf.15841. Epub 2020 May 27.
Abstract
Oral swabs, sputum, and blood samples from 18 asymptomatic and symptomatic patients with SARS-CoV-2 infection were examined using RT-PCR testing in order to assess the risk of transfusion-related transmission. In asymptomatic patients as well as patients with flu-like symptoms and fever, no SARS-CoV-2 RNA could be detected in the blood or serum despite a clearly positive result in all throat swabs. As patients with symptoms of infectious disease will not be admitted to blood donation, the risk for transfusion transmission of SARS-CoV-2 seems to be negligible.
摘要
为了评估与输血相关的传播风险，对 18 名无症状和有症状的 SARS-CoV-2 感染患者的口腔拭子、痰液和血液样本进行了 RT-PCR 检测。在无症状患者以及有流感样症状和发热的患者中，尽管所有咽拭子均呈明显阳性，但血液或血清中均未检测到 SARS-CoV-2 RNA。由于有症状的传染病患者不会被收治为献血者，因此 SARS-CoV-2 的输血传播风险似乎可以忽略不计。
相似文献
1
SARS-CoV-2 asymptomatic and symptomatic patients and risk for transfusion transmission.SARS-CoV-2 无症状和有症状患者及输血传播风险。
Transfusion. 2020 Jun;60(6):1119-1122. doi: 10.1111/trf.15841. Epub 2020 May 27.
2
No evidence of SARS-CoV-2 transfusion transmission despite RNA detection in blood donors showing symptoms after donation.尽管在献血后出现症状的献血者血液中检测到RNA，但尚无证据表明SARS-CoV-2可通过输血传播。
Blood. 2020 Oct 15;136(16):1888-1891. doi: 10.1182/blood.2020008230.
3
Descriptive, Retrospective Study of the Clinical Characteristics of Asymptomatic COVID-19 Patients.无症状 COVID-19 患者的临床特征描述性、回顾性研究。
mSphere. 2020 Oct 7;5(5):e00922-20. doi: 10.1128/mSphere.00922-20.
4
Virus shedding dynamics in asymptomatic and mildly symptomatic patients infected with SARS-CoV-2.无症状和轻度症状 SARS-CoV-2 感染患者的病毒脱落动力学。
Clin Microbiol Infect. 2020 Nov;26(11):1556.e1-1556.e6. doi: 10.1016/j.cmi.2020.07.008. Epub 2020 Jul 9.
5
Reliability of induced sputum test is greater than that of throat swab test for detecting SARS-CoV-2 in patients with COVID-19: A multi-center cross-sectional study.诱导痰检测的可靠性大于咽拭子检测，可用于检测 COVID-19 患者的 SARS-CoV-2：一项多中心横断面研究。
Virulence. 2020 Dec;11(1):1394-1401. doi: 10.1080/21505594.2020.1831342.
6
Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility.在一家专业护理机构中出现的 SARS-CoV-2 感染前驱期和传播。
N Engl J Med. 2020 May 28;382(22):2081-2090. doi: 10.1056/NEJMoa2008457. Epub 2020 Apr 24.
7
COVID-19 transmission and blood transfusion: A case report.COVID-19 传播与输血：病例报告。
J Infect Public Health. 2020 Nov;13(11):1678-1679. doi: 10.1016/j.jiph.2020.05.001. Epub 2020 May 13.
8
A randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVID Trial): A structured summary of a study protocol for a randomised controlled trial.一项评估褪黑素预防高危接触者 SARS-CoV-2 感染有效性的随机多中心临床试验（MeCOVID 试验）：一项随机对照试验研究方案的结构化总结。
Trials. 2020 Jun 3;21(1):466. doi: 10.1186/s13063-020-04436-6.
9
Report of Positive Placental Swabs for SARS-CoV-2 in an Asymptomatic Pregnant Woman with COVID-19.SARS-CoV-2 阳性胎盘拭子在 COVID-19 无症状孕妇中的报告。
Medicina (Kaunas). 2020 Jun 22;56(6):306. doi: 10.3390/medicina56060306.
10
Management of Care for Neonates Born to SARS-CoV-2 Positive Women with or without Clinical Symptoms (COVID-19).对感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的有或无临床症状（新冠肺炎）女性所生新生儿的护理管理
Klin Padiatr. 2020 Jul;232(4):173-177. doi: 10.1055/a-1168-2845. Epub 2020 Jun 5.
引用本文的文献
1
Occurrence and clinical correlates of SARS-CoV-2 viremia in two German patient cohorts.两个德国患者队列中SARS-CoV-2病毒血症的发生情况及临床相关性
Emerg Microbes Infect. 2025 Dec;14(1):2459137. doi: 10.1080/22221751.2025.2459137. Epub 2025 Feb 10.
2
Predicting severe COVID-19 using readily available admission indicators: SpO2/FiO2 ratio, comorbidity index, and gender.使用易于获取的入院指标预测重症新型冠状病毒肺炎：氧合指数、合并症指数和性别。
Exp Biol Med (Maywood). 2024 Nov 20;249:10193. doi: 10.3389/ebm.2024.10193. eCollection 2024.
3
Characteristics of HPC(A) product obtained from a donor with SARS-CoV-2 infection and outcome of autologous transplant.从 SARS-CoV-2 感染供者获得的 HPC(A) 产品的特征和自体移植的结果。
Stem Cell Res Ther. 2024 Aug 13;15(1):251. doi: 10.1186/s13287-024-03872-4.
4
Epidemiology of severe acute respiratory syndrome-related coronavirus 2 antibodies in healthy blood donors and their follow-up.健康献血者中严重急性呼吸综合征相关冠状病毒2抗体的流行病学及其随访
Asian J Transfus Sci. 2023 Jul-Dec;17(2):182-188. doi: 10.4103/ajts.ajts_9_22. Epub 2022 Sep 28.
5
IFN-stimulated metabolite transporter ENT3 facilitates viral genome release.IFN 刺激的代谢物转运蛋白 ENT3 促进病毒基因组释放。
EMBO Rep. 2023 Mar 6;24(3):e55286. doi: 10.15252/embr.202255286. Epub 2023 Jan 18.
6
Neither COVID-19, nor cryopreservation, prevented allogeneic product infusion: A report from the National Marrow Donor Program.无论是 COVID-19 还是冷冻保存，都未能阻止异基因产品输注：来自国家骨髓供者计划的报告。
Front Immunol. 2022 Sep 20;13:937900. doi: 10.3389/fimmu.2022.937900. eCollection 2022.
7
Low SARS-CoV-2 Antibodies in Blood Donors After the First 6 Months of COVID-19 Epidemic in the Tobruk Region, Eastern Libya.利比亚东部托布鲁克地区新冠疫情爆发头6个月后献血者体内的新冠病毒抗体水平较低。
Disaster Med Public Health Prep. 2022 Jul 27:1-2. doi: 10.1017/dmp.2022.180.
8
No Evidence of SARS-CoV-2 Among Flies or Cockroaches in Households Where COVID-19 Positive Cases Resided.家庭中苍蝇或蟑螂没有新冠病毒的证据，这些家庭有新冠阳性病例居住。
J Med Entomol. 2022 Jul 13;59(4):1479-1483. doi: 10.1093/jme/tjac055.
9
Inactivation of SARS-CoV-2 in All Blood Components Using Amotosalen/Ultraviolet A Light and Amustaline/Glutathione Pathogen Reduction Technologies.使用氨甲环酸/紫外线A光和氨磷汀/谷胱甘肽病原体灭活技术对所有血液成分中的严重急性呼吸综合征冠状病毒2进行灭活。
Pathogens. 2022 Apr 28;11(5):521. doi: 10.3390/pathogens11050521.
10
Blood Transfusion Reactions-A Comprehensive Review of the Literature including a Swiss Perspective.输血反应——包括瑞士视角的文献综述
J Clin Med. 2022 May 19;11(10):2859. doi: 10.3390/jcm11102859.
本文引用的文献
1
Detectable Serum Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load (RNAemia) Is Closely Correlated With Drastically Elevated Interleukin 6 Level in Critically Ill Patients With Coronavirus Disease 2019.在重症 2019 冠状病毒病患者中，可检测到的血清严重急性呼吸综合征冠状病毒 2 病毒载量（RNAemia）与显著升高的白细胞介素 6 水平密切相关。
Clin Infect Dis. 2020 Nov 5;71(8):1937-1942. doi: 10.1093/cid/ciaa449.
2
Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity.血液中可检测到的 2019-nCoV 病毒 RNA 是进一步临床严重程度的强烈指标。
Emerg Microbes Infect. 2020 Feb 26;9(1):469-473. doi: 10.1080/22221751.2020.1732837. eCollection 2020.
3
Asymptomatic cases in a family cluster with SARS-CoV-2 infection.新型冠状病毒肺炎（SARS-CoV-2）感染家庭聚集性病例中的无症状感染者。
Lancet Infect Dis. 2020 Apr;20(4):410-411. doi: 10.1016/S1473-3099(20)30114-6. Epub 2020 Feb 19.
4
Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea.韩国前两例 SARS-CoV-2 感染患者的病毒载量动力学。
J Korean Med Sci. 2020 Feb 24;35(7):e86. doi: 10.3346/jkms.2020.35.e86.
5
Evidence of SARS-CoV-2 Infection in Returning Travelers from Wuhan, China.从中国武汉返回的旅行者中新型冠状病毒感染的证据。
N Engl J Med. 2020 Mar 26;382(13):1278-1280. doi: 10.1056/NEJMc2001899. Epub 2020 Feb 18.
6
Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes.2019-nCoV 感染患者的分子和血清学调查：多种脱落途径的意义。
Emerg Microbes Infect. 2020 Feb 17;9(1):386-389. doi: 10.1080/22221751.2020.1729071. eCollection 2020.
7
Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany.德国一名无症状接触者传播2019新型冠状病毒感染
N Engl J Med. 2020 Mar 5;382(10):970-971. doi: 10.1056/NEJMc2001468. Epub 2020 Jan 30.
8
Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR.实时 RT-PCR 检测 2019 新型冠状病毒（2019-nCoV）
Euro Surveill. 2020 Jan;25(3). doi: 10.2807/1560-7917.ES.2020.25.3.2000045.
9
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.中国武汉地区 2019 年新型冠状病毒感染患者的临床特征。
Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
10
MERS coronavirus: diagnostics, epidemiology and transmission.中东呼吸综合征冠状病毒：诊断、流行病学及传播
Virol J. 2015 Dec 22;12:222. doi: 10.1186/s12985-015-0439-5.
Zotero 插件