Department of Animal, Plant and Soil Sciences, Australian Research Council Centre of Excellence in Plant Energy Biology, School of Life Sciences, La Trobe University, Bundoora, Victoria, Australia.
Department of Animal Science and Technology, Grassland Science, China Agricultural University, Beijing 100193, People's Republic of China.
Philos Trans R Soc Lond B Biol Sci. 2020 Jun 22;375(1801):20190410. doi: 10.1098/rstb.2019.0410. Epub 2020 May 4.
Retrograde signalling refers to the regulation of nuclear gene expression in response to functional changes in organelles. In plants, the two energy-converting organelles, mitochondria and chloroplasts, are tightly coordinated to balance their activities. Although our understanding of components involved in retrograde signalling has greatly increased in the last decade, studies on the regulation of the two organelle signalling pathways have been largely independent. Thus, the mechanism of how mitochondrial and chloroplastic retrograde signals are integrated is largely unknown. Here, we summarize recent findings on the function of mitochondrial signalling components and their links to chloroplast retrograde responses. From this, a picture emerges showing that the major regulators are integrators of both organellar retrograde signalling pathways. This article is part of the theme issue 'Retrograde signalling from endosymbiotic organelles'.
逆行信号是指针对细胞器功能变化，细胞核基因表达的调节。在植物中，两种能量转换细胞器，线粒体和叶绿体，紧密协调以平衡它们的活动。尽管在过去十年中，我们对逆行信号传导涉及的成分的理解有了很大的提高，但对这两个细胞器信号通路的调节研究在很大程度上是相互独立的。因此，线粒体和叶绿体逆行信号如何整合的机制在很大程度上是未知的。在这里，我们总结了线粒体信号成分的功能及其与叶绿体逆行反应的联系的最新发现。由此可见，主要的调节因子是两个细胞器逆行信号通路的整合者。本文是主题为“内共生细胞器逆行信号”的一部分。
