韩国多中心临床分离株的抗真菌药敏试验及突变菌株
Antifungal Susceptibility Tests and the Mutant Strains among Clinical Isolates from Korean Multicenters.
作者信息
Won Eun Jeong, Joo Min Young, Lee Dain, Kim Mi-Na, Park Yeon-Joon, Kim Soo Hyun, Shin Myung Geun, Shin Jong Hee
机构信息
Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Korea.
Department of Parasitology and Tropical Medicine, Chonnam National University Medical School, Gwangju, Korea.
出版信息
Mycobiology. 2020 Apr 10;48(2):148-152. doi: 10.1080/12298093.2020.1744955. eCollection 2020.
Abstract
We investigated the antifungal susceptibilities and the mutant strains among clinical isolates obtained from 10 university hospitals in Korea. Of the 84 isolates examined, two itraconazole-resistant isolates were found with no amino acid substitution in the genes. However, 19 (23.2%) azole-susceptible isolates harbored amino acid substitutions Nine isolates harbored one to five mutations in with high polymorphism, and 11 isolates exhibited the same Q42L mutation in . Overall, a low azole resistance rate and high frequency of amino acid substitutions were observed in the azole-susceptible isolates in Korea.
摘要
我们调查了从韩国10所大学医院获取的临床分离株的抗真菌药敏性及突变菌株。在所检测的84株分离株中，发现2株对伊曲康唑耐药的分离株，其基因中无氨基酸替换。然而，19株（23.2%）对唑类敏感的分离株存在氨基酸替换。9株分离株在具有高多态性的基因中有1至5个突变，11株分离株在基因中表现出相同的Q42L突变。总体而言，在韩国对唑类敏感的分离株中观察到较低的唑类耐药率和较高频率的氨基酸替换。
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