College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai'an, China.
College of Agriculture, Liaocheng University, Liaocheng, China.
Mol Reprod Dev. 2020 May;87(5):525-533. doi: 10.1002/mrd.23347. Epub 2020 May 3.
Lin28a and Lin28b, homologs of the Caenorhabditis elegans Lin28 gene, play important roles in cell pluripotency, reprogramming, and tumorigenicity. Recently, genome-wide association and transgenic studies showed that Lin28a and/or Lin28b gene were involved in the onset of mammalian puberty, the stage representing the attainment of reproduction capacity; however, the detailed mechanism of these genes in mammalian puberty remains largely unknown. The present paper reviews the research progress on the roles of Lin28a/b genes in the onset of mammalian puberty by analyzing the results coming from gene expression patterns, mutations, and transgenic studies, and put forward possible pathways for further studies on their roles in animal reproduction.
Lin28a 和 Lin28b 是秀丽隐杆线虫 Lin28 基因的同源物，在细胞多能性、重编程和致瘤性中发挥重要作用。最近，全基因组关联和转基因研究表明，Lin28a 和/或 Lin28b 基因参与了哺乳动物青春期的发生，这一阶段代表了获得生殖能力的阶段；然而，这些基因在哺乳动物青春期中的详细作用机制在很大程度上仍不清楚。本文通过分析基因表达模式、突变和转基因研究的结果，综述了 Lin28a/b 基因在哺乳动物青春期发生中的作用的研究进展，并提出了进一步研究其在动物生殖中作用的可能途径。
