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Reply to Letter to the Editor: "Don't judge too RAShly: the multifaceted role of the renin-angiotensin system and its therapeutic potential in COVID-19".致编辑信件的回复：“勿轻率评判：肾素 - 血管紧张素系统的多面作用及其在 COVID - 19 中的治疗潜力”
Am J Physiol Lung Cell Mol Physiol. 2020 May 1;318(5):L1029-L1030. doi: 10.1152/ajplung.00133.2020.
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Call for Papers: The Pathophysiology of COVID-19 and SARS-CoV-2 Infection.征文启事：新型冠状病毒肺炎及严重急性呼吸综合征冠状病毒2感染的病理生理学
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本文引用的文献

1
Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study.113 例新冠肺炎死亡患者的临床特征：回顾性研究。
BMJ. 2020 Mar 26;368:m1091. doi: 10.1136/bmj.m1091.
2
Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan, China: a retrospective study.中国武汉 2019 年冠状病毒病死亡和康复病例的临床特征：回顾性研究。
Chin Med J (Engl). 2020 Jun 5;133(11):1261-1267. doi: 10.1097/CM9.0000000000000824.
3
Renin-Angiotensin System Blockers and the COVID-19 Pandemic: At Present There Is No Evidence to Abandon Renin-Angiotensin System Blockers.肾素-血管紧张素系统阻滞剂与 COVID-19 大流行：目前尚无证据表明应放弃使用肾素-血管紧张素系统阻滞剂。
Hypertension. 2020 Jun;75(6):1382-1385. doi: 10.1161/HYPERTENSIONAHA.120.15082. Epub 2020 Mar 25.
4
Covid-19 infection and mortality: a physiologist's perspective enlightening clinical features and plausible interventional strategies.新型冠状病毒肺炎感染与死亡率：生理学家视角下的临床特征与可行干预策略解析
Am J Physiol Lung Cell Mol Physiol. 2020 May 1;318(5):L1020-L1022. doi: 10.1152/ajplung.00097.2020. Epub 2020 Mar 24.
5
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.中国武汉成人 COVID-19 住院患者的临床病程和死亡危险因素：一项回顾性队列研究。
Lancet. 2020 Mar 28;395(10229):1054-1062. doi: 10.1016/S0140-6736(20)30566-3. Epub 2020 Mar 11.
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）进入细胞依赖于 ACE2 和 TMPRSS2，可被一种临床验证的蛋白酶抑制剂所阻断。
Cell. 2020 Apr 16;181(2):271-280.e8. doi: 10.1016/j.cell.2020.02.052. Epub 2020 Mar 5.
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Clinical Characteristics of Coronavirus Disease 2019 in China.《中国 2019 年冠状病毒病临床特征》
N Engl J Med. 2020 Apr 30;382(18):1708-1720. doi: 10.1056/NEJMoa2002032. Epub 2020 Feb 28.
8
Therapeutic time window for angiotensin-(1-7) in acute lung injury.血管紧张素-（1-7）在急性肺损伤中的治疗时间窗
Br J Pharmacol. 2016 May;173(10):1618-28. doi: 10.1111/bph.13462. Epub 2016 Mar 21.
9
Angiotensin-(1-7) protects from experimental acute lung injury.血管紧张素-(1-7)可预防实验性急性肺损伤。
Crit Care Med. 2013 Nov;41(11):e334-43. doi: 10.1097/CCM.0b013e31828a6688.
10
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury.血管紧张素转换酶2（ACE2）在严重急性呼吸综合征冠状病毒诱导的肺损伤中的关键作用。
Nat Med. 2005 Aug;11(8):875-9. doi: 10.1038/nm1267. Epub 2005 Jul 10.

Don't judge too RAShly: the multifaceted role of the renin-angiotensin system and its therapeutic potential in COVID-19.

作者信息

Walther Thomas, Kuebler Wolfgang M

机构信息

Department of Pharmacology and Therapeutics, School of Medicine and School of Pharmacy, University College Cork, Cork, Ireland.

Institute of Medical Biochemistry and Molecular Biology, University Medicine Greifswald, Greifswald, Germany.

出版信息

Am J Physiol Lung Cell Mol Physiol. 2020 May 1;318(5):L1023-L1024. doi: 10.1152/ajplung.00118.2020.

DOI:10.1152/ajplung.00118.2020
PMID:32364441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7215092/
Abstract
摘要