Department of Pharmacy, "G. d'Annunzio" University Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
Department of Medicine and Aging Sciences, "G. d'Annunzio" University Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
Int J Environ Res Public Health. 2020 Apr 29;17(9):3105. doi: 10.3390/ijerph17093105.
: Arsenic is a toxic metalloid element widely distributed throughout the environment. Arsenic contaminated water has become an ongoing public health issue affecting hundred million people worldwide. The aim of this paper was to summarize the evidence in the association between arsenic metabolites and urinary tract cancer risk. : A systematic review was conducted searching for observational studies that evaluated the association of arsenic metabolites and urinary tract cancer. Risk estimates from individual studies were pooled by using random effects models. : All the metabolites considered in this study resulted to be significantly associated to urothelial cancer, respectively: IA% 3.51 (1.21-5.82) ( = 0.003), MMA with WMD = 2.77 (1.67-3.87) ( < 0.001) and DMA with WMD = -4.56 (-7.91-1.22) ( = 0.008). : Arsenic metabolites are significantly associated to urothelial cancer. Future studies will help to verify the independent association(s) between arsenic metabolites and urothelial cancer.
砷是一种广泛分布于环境中的有毒类金属元素。受砷污染的水已成为影响全球数亿人口的公共卫生问题。本文旨在总结砷代谢物与尿路癌风险之间关联的证据。
系统检索了评估砷代谢物与尿路癌关联性的观察性研究，采用随机效应模型对各研究的风险估计值进行了合并。
本研究考虑的所有代谢物均与尿路上皮癌显著相关，分别为：IA% 3.51（1.21-5.82）（=0.003）、MMA 的 WMD=2.77（1.67-3.87）（<0.001）和 DMA 的 WMD=-4.56（-7.91-1.22）（=0.008）。
砷代谢物与尿路上皮癌显著相关。未来的研究将有助于验证砷代谢物与尿路上皮癌之间的独立关联。
