饮酒与上尿路尿路上皮癌风险

Alcohol consumption and risk of upper-tract urothelial cancer.

作者信息

Zaitsu Masayoshi, Kawachi Ichiro, Takeuchi Takumi, Kobayashi Yasuki

机构信息

Department of Public Health, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan; Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, 7th floor, Boston, MA, 02115 USA.

Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, 7th floor, Boston, MA, 02115 USA.

出版信息

Cancer Epidemiol. 2017 Jun;48:36-40. doi: 10.1016/j.canep.2017.03.002. Epub 2017 Mar 29.

DOI:10.1016/j.canep.2017.03.002

PMID:28364670

Abstract

BACKGROUND

Upper-tract urothelial cancer (UTUC), which includes renal pelvic cancer and ureter cancer, is a rare cancer and its prognosis is poor. Smoking and high-risk occupations (e.g., printing and dyestuff working which involves exposure to aniline dyes) are well-known risk factors for UTUC. However, the risk of alcohol consumption in UTUC remains unclear. This study aimed to determine whether alcohol consumption is an independent risk factor for UTUC.

METHODS

The study was a case-control study which used the nationwide clinical inpatient database of the Rosai Hospital group in Japan. We identified 1569 cases and 506,797 controls between 1984 and 2014. We estimated the odds ratio (OR) and 95% confidence interval (95%CI) of alcohol consumption for UTUC - never, up to 15g/day, >15-30g/day, or >30g/day - using unconditional logistic regression. We adjusted for the following covariates: age, sex, study period, hospital, history of smoking, and high-risk occupation.

RESULTS

The risk of UTUC was significantly higher in ever-drinkers compared with never-drinkers (OR=1.23, 95%CI, 1.08-1.40; P=0.001). Compared with never-drinkers, the risk threshold for UTUC was >15g of alcohol consumption per day (equivalent to 6 ounces of Japanese sake containing 23g of alcohol). A dose-response was observed (P<0.001).

CONCLUSION

Alcohol consumption may be an independent risk factor for UTUC, with a low-risk threshold of 15g of alcohol per day.

摘要

背景

上尿路尿路上皮癌（UTUC），包括肾盂癌和输尿管癌，是一种罕见癌症，其预后较差。吸烟和高危职业（如涉及接触苯胺染料的印刷和染料工作）是UTUC的众所周知的危险因素。然而，UTUC中饮酒的风险仍不清楚。本研究旨在确定饮酒是否是UTUC的独立危险因素。

方法

该研究是一项病例对照研究，使用了日本罗萨伊医院集团的全国临床住院患者数据库。我们在1984年至2014年间确定了1569例病例和506797例对照。我们使用无条件逻辑回归估计了UTUC（从不饮酒、每天饮酒量达15克、每天饮酒量>15 - 30克或每天饮酒量>30克）饮酒的优势比（OR）和95%置信区间（95%CI）。我们对以下协变量进行了调整：年龄、性别、研究时期、医院、吸烟史和高危职业。