The Roma Population Living in Segregated Settlements in Eastern Slovakia Has a Higher Prevalence of Metabolic Syndrome, Kidney Disease, Viral Hepatitis B and E, and Some Parasitic Diseases Compared to the Majority Population.

: The Roma population is one of the largest marginalized population groups in Europe. The aim of our work was to summarize the morbidity of lifestyle-related diseases and infectious diseases in the Roma population living in segregated settlements. : We used data from the cross-sectional study HepaMeta, in which we examined 452 Roma subjects with an average age of 34.7 ± 9.1 years, 35.2% of which were men, and 403 non-Roma subjects with an average age of 33.5 ± 7.4 years, 45.9% of which were men. We collected data by means of a questionnaire, anthropometric measures, and we analyzed blood and urine samples. : Roma subjects had a higher incidence of metabolic syndrome (RR: 1.478 (1.159-1.885), < 0.0001), obesity or waist circumference >94 cm in men/80 cm in women (RR: 1.287 (1.127-1.470), < 0.0001), and HDL-C < 1.03 mmol/L in men or <1.29 in women (RR: 2.004 (1.730-2.321), < 0.0001) than their non-Roma counterparts. Subjects of the Roma population were more frequently diagnosed with kidney disease (RR: 1.216 (1.096-1.349), < 0.0001), HBsAg positivity (RR: 4.468 (2.373-8.415), < 0.0001), anti HBc IgG positivity (RR: 3.13 (2.598-4.224), < 0.0001), and anti HEV positivity (RR: 2.972 (1.226-7.287), < 0.0001). Serological markers of infection and spp. were observed much more frequently among Roma than non-Roma subjects (RR: 1.868 (1.520-2.296), < 0.0001, for ; and RR: 21.812 (8.097-58.761), < 0.0001, for spp.). : Poor socio-economic conditions, an unhealthy lifestyle, and barriers precluding access to healthcare are factors that affect the Roma population in settlements and lead to an increased prevalence of metabolic syndrome and its components, kidney disease, viral hepatitis B and E, and some parasitic diseases.