Department of Obstetrics and Gynecology, University Medicine Greifswald, Greifswald, Germany.
Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Anticancer Res. 2020 May;40(5):2801-2812. doi: 10.21873/anticanres.14253.
BACKGROUND/AIM: The influence of a polyurethane-based tissue adhesive (TissuGlu®) on common complications following breast surgery was investigated.
Within a Randomized-Controlled-Trial 70 women (n=35 TissuGlu®, n=35 drain) underwent a mastectomy with or without sentinel lymph node excision (SLNE), followed by a 90-day postoperative follow-up.
Postoperative interventions: Non-inferiority of the application of TissuGlu® was seen. Pain-Level/ Hospitalization: A statistically significant pain reduction from day four onwards (p<0.001) and a shorter hospitalization period (p<0.001) was observed. In contrast, the TissuGlu® group showed increased mean puncture incidence (p=0.013), and increased puncture volume (p=0.021).
Application of the polyurethane-based tissue adhesive TissuGlu® after mastectomy, with or without SLNE, showed potential for improvement of the clinical outcome. In contrast, high intervention rates and increased puncture volume, caused by recurring seromas following application of the surgical adhesive TissuGlu®, have a negative impact on the patient-specific convalescence.
背景/目的：研究了一种基于聚氨酯的组织粘合剂（TissuGlu®）对乳房手术后常见并发症的影响。
在一项随机对照试验中，70 名女性（n=35 TissuGlu®，n=35 引流）接受了乳房切除术和/或前哨淋巴结切除术（SLNE），并在术后 90 天进行随访。
术后干预：TissuGlu®的应用具有非劣效性。疼痛水平/住院时间：从第四天开始观察到疼痛明显减轻（p<0.001），住院时间缩短（p<0.001）。相比之下，TissuGlu®组的穿刺发生率（p=0.013）和穿刺量（p=0.021）增加。
在乳房切除术和/或 SLNE 后应用基于聚氨酯的组织粘合剂 TissuGlu®显示出改善临床结果的潜力。相比之下，由于应用手术粘合剂 TissuGlu®后反复发作的血清肿，导致高干预率和穿刺量增加，对患者特定的康复产生负面影响。
