TissuGlu®手术粘合剂在有或无淋巴结清扫的乳房切除术中的应用。
The Use of TissuGlu® Surgical Adhesive for Mastectomy With or Without Lymphonodectomy.
作者信息
Ohlinger Ralf, Gieron Leonie, Rutkowski Rico, Kohlmann Thomas, Zygmunt Marek, Unger Julia
机构信息
Clinic and Polyclinic for Obstetrics and Gynecology, University Medicine Greifswald, Greifswald, Germany.
Department of Oral and Maxillofacial Surgery/Plastic Surgery, University Medicine Greifswald, Greifswald, Germany.
出版信息
In Vivo. 2018 May-Jun;32(3):625-631. doi: 10.21873/invivo.11284.
BACKGROUND/AIM: Using drains after breast surgery is a preventive, but invasive measure to reduce seroma formation. A polyurethane-based tissue adhesive (TissuGlu®) might facilitate drainage-free wound healing after mastectomy in a non-invasive manner.
PATIENTS AND METHODS
Retrospectively, data from 84 patients (42 receiving TissuGlu®, 42 receiving a drainage) who underwent mastectomy, were collected (90 days postoperative follow-up). Study endpoints were defined as the number of fluid-related postoperative clinical interventions, cumulative volume of postoperative wound fluid, duration of hospitalization and postoperative complications.
RESULTS
In the entirety of postoperative interventions, no significant difference could be demonstrated (p=0.298). The drainage arm showed significantly less seroma aspirations (p=0.024) and complications (p=0.012). A significantly reduced length of hospitalization (p<0.001) and less cumulative wound secretion volume (p<0.001) appeared in the TissuGlu® group.
CONCLUSION
The polyurethane-based tissue adhesive is a less invasive alternative to drain use in mastectomy.
背景/目的：乳房手术后使用引流管是一种预防措施，但具有侵入性，用于减少血清肿形成。一种基于聚氨酯的组织粘合剂（TissuGlu®）可能以非侵入性方式促进乳房切除术后无引流的伤口愈合。
患者与方法
回顾性收集84例行乳房切除术患者的数据（42例使用TissuGlu®，42例使用引流管）（术后随访90天）。研究终点定义为与液体相关的术后临床干预次数、术后伤口液体累积量、住院时间和术后并发症。
结果
在所有术后干预中，未显示出显著差异（p = 0.298）。引流组的血清肿抽吸次数（p = 0.024）和并发症（p = 0.012）显著更少。TissuGlu®组的住院时间显著缩短（p < 0.001），伤口分泌物累积量更少（p < 0.001）。
结论
基于聚氨酯的组织粘合剂是乳房切除术中使用引流管的一种侵入性较小的替代方法。
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