Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan
Anticancer Res. 2020 May;40(5):2881-2887. doi: 10.21873/anticanres.14264.
BACKGROUND/AIM: This study evaluated the prognostic significance of preoperative neutrophil-to-lymphocyte ratio (NLR) and CD8 tumor-infiltrating lymphocytes (TILs), and whether preoperative NLR was associated with CD8 TILs in biliary tract cancers (BTCs).
A total of 154 patients with BTCs who underwent surgery were enrolled in this study. We obtained neutrophil and lymphocyte counts, and calculated NLR from preoperative peripheral blood samples. CD8 TILs were identified by immunohistochemical staining.
The overall survival (OS) and recurrence-free survival (RFS) of patients with high NLR were shorter than those with low NLR. The OS and RFS of patients with high CD8 TILs were longer than those with low CD8 TILs. Preoperative NLR and CD8 TILs were negatively correlated.
NLR and CD8 TILs were associated with OS and RFS in BTCs. NLR can predict CD8 TILs infiltrating the cancer microenvironment.
背景/目的：本研究评估了术前中性粒细胞与淋巴细胞比值（NLR）和 CD8 肿瘤浸润淋巴细胞（TILs）对胆道癌（BTC）患者的预后意义，以及术前 NLR 是否与 CD8 TILs 相关。
本研究共纳入 154 例行手术治疗的 BTC 患者。我们从术前外周血样本中获得中性粒细胞和淋巴细胞计数，并计算 NLR。通过免疫组织化学染色鉴定 CD8 TILs。
高 NLR 组患者的总生存期（OS）和无复发生存期（RFS）均短于低 NLR 组。高 CD8 TILs 组患者的 OS 和 RFS 长于低 CD8 TILs 组。术前 NLR 与 CD8 TILs 呈负相关。
NLR 和 CD8 TILs 与 BTC 的 OS 和 RFS 相关。NLR 可预测肿瘤微环境中 CD8 TILs 的浸润情况。
