Ahmed Jubair, Gultekinoglu Merve, Edirisinghe Mohan
Department of Mechanical Engineering, University College London, London, UK.
Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2024 Jan-Feb;16(1):e1916. doi: 10.1002/wnan.1916. Epub 2023 Aug 8.
Centrifugal spinning is a technology used to generate small diameter fibers and has been extensively studied for its vast applications in biomedical engineering. Centrifugal spinning is known for its rapid production rate and has inspired the creation of other technologies which leverage the high-speed rotation, namely Pressurized Gyration. Pressurized gyration incorporates a unique applied gas pressure which serves to provide additional control over the fiber production process. The resulting fibers are uniquely suitable for a range of healthcare-related applications that are thoroughly discussed in this work, which involve scaffolds for tissue engineering, solid dispersions for drug delivery, antimicrobial meshes for filtration and bandage-like fibrous coverings for wound healing. In this review, the notable recent developments in centrifugal spinning and pressurized gyration are presented and how these technologies are being used to further the range of uses of biomaterials engineering, for example the development of core-sheath fabrication techniques for multi-layered fibers and the combination with electrospinning to produce advanced fiber mats. The enormous potential of these technologies and their future advancements highlights how important they are in the biomedical discipline. This article is categorized under: Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Biology-Inspired Nanomaterials > Lipid-Based Structures.
离心纺丝是一种用于制造小直径纤维的技术，因其在生物医学工程中的广泛应用而受到广泛研究。离心纺丝以其快速的生产速度而闻名，并启发了其他利用高速旋转的技术的创造，即加压旋转。加压旋转采用独特的外加气体压力，用于对纤维生产过程提供额外的控制。所得纤维特别适用于一系列与医疗保健相关的应用，本文对此进行了详细讨论，这些应用包括组织工程支架、药物递送的固体分散体、过滤用抗菌网以及伤口愈合用绷带状纤维覆盖物。在这篇综述中，介绍了离心纺丝和加压旋转最近的显著进展，以及这些技术如何被用于拓展生物材料工程的应用范围，例如开发用于多层纤维的核壳制造技术以及与静电纺丝相结合以生产先进的纤维垫。这些技术的巨大潜力及其未来的进展凸显了它们在生物医学领域的重要性。本文分类如下：可植入材料与手术技术>组织修复与置换中的纳米技术；纳米技术在生物学中的应用>生物学中的纳米尺度系统；仿生纳米材料>基于脂质的结构。
