Siddamreddy Suman, Meegada Sreenath, Syed Anum, Sarwar Mujtaba, Muppidi Vijayadershan
Internal Medicine, Baptist Health Medical Center, Little Rock, USA.
Internal Medicine, The University of Texas Health Science Center/Christus Good Shepherd Medical Center, Longview, USA.
Cureus. 2020 Mar 31;12(3):e7487. doi: 10.7759/cureus.7487.
Gallbladder neuroendocrine neoplasms (GB-NEN) are very rare neuroendocrine tumors (NETs). GB-NEN can present as carcinoid or typical/atypical carcinoid or small cell carcinoma. Most of the GB-NENs present as gall bladder polyps or stones with right upper quadrant pain, nausea and non-specific symptoms which leads to clinical misdiagnosis. Considering the rare occurrence of GB-NENs, and lack of multi-center research data there is no unified standard for identification and treatment. We here present an 84-year-old male presenting with right upper quadrant and epigastric pain, and eventually diagnosed with mixed cell (more of small cells mixed with intermediate to large cells) neuroendocrine cancer of gall bladder.
胆囊神经内分泌肿瘤（GB-NEN）是非常罕见的神经内分泌肿瘤（NET）。GB-NEN可表现为类癌、典型/非典型类癌或小细胞癌。大多数GB-NEN表现为胆囊息肉或结石，伴有右上腹疼痛、恶心及非特异性症状，这导致临床误诊。鉴于GB-NEN发病率低，且缺乏多中心研究数据，目前尚无统一的诊断和治疗标准。我们在此报告一例84岁男性患者，以右上腹和上腹部疼痛就诊，最终被诊断为混合细胞型（更多为小细胞与中到大细胞混合）胆囊神经内分泌癌。
