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同步发生但相互独立的胆囊神经内分泌肿瘤与高级别发育异常/腺瘤：一例报告

Synchronous but separate neuroendocrine tumor and high-grade dysplasia/adenoma of the gall bladder: A case report.

作者信息

Hsiao Tsung-Hsien, Wu Chao-Chuan, Tseng Hui-Hwa, Chen Jiann-Hwa

机构信息

Division of Gastroenterology and Hepatology, Taipei Tzu Chi Hospital, New Taipei City 231, Taiwan.

Department of Surgery, Taipei Tzu Chi Hospital, New Taipei City 231, Taiwan.

出版信息

World J Clin Cases. 2022 Mar 6;10(7):2322-2329. doi: 10.12998/wjcc.v10.i7.2322.

DOI:10.12998/wjcc.v10.i7.2322
PMID:35321155
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8895191/
Abstract

BACKGROUND

Gall bladder neuroendocrine tumors (GB-NETs) are rare, accounting for less than 0.5% of all NETs. They usually lack specific symptoms and are difficult to diagnose preoperatively. In most cases, GB-NETs are incidentally found after cholecystectomy for large polyps or cholelithiasis, causing acute or chronic cholecystitis. The coexistence of GB-NET and GB adenocarcinoma is very rare.

CASE SUMMARY

We report a case of synchronous but separate GB-NET and adenoma with high-grade dysplasia in a patient who had undergone surgery for a progressively growing GB polypoid lesion. To the best of our knowledge, simultaneous separation of NETs and cancer in the GB has not been reported.

CONCLUSION

Coexistent GB carcinoid tumor and adenocarcinoma is rare. A surveillance program is needed for these large GB polyps.

摘要

背景

胆囊神经内分泌肿瘤（GB-NETs）较为罕见，占所有神经内分泌肿瘤的比例不到0.5%。它们通常缺乏特异性症状，术前难以诊断。在大多数情况下，GB-NETs是在因大息肉或胆石症行胆囊切除术时偶然发现的，这些息肉或胆石症可导致急性或慢性胆囊炎。GB-NET与GB腺癌并存的情况非常罕见。

病例摘要

我们报告一例在因胆囊息肉样病变逐渐增大而接受手术的患者中，同时存在但相互独立的GB-NET和高级别发育异常腺瘤的病例。据我们所知，胆囊内神经内分泌肿瘤和癌症同时分离的情况尚未见报道。

结论

GB类癌肿瘤与腺癌并存的情况罕见。对于这些较大的胆囊息肉需要进行监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd74/8895191/00543463379d/WJCC-10-2322-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd74/8895191/74c0a0111c40/WJCC-10-2322-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd74/8895191/7588dca825c0/WJCC-10-2322-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd74/8895191/c0005c184a08/WJCC-10-2322-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd74/8895191/b60ccdf0b598/WJCC-10-2322-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd74/8895191/00543463379d/WJCC-10-2322-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd74/8895191/74c0a0111c40/WJCC-10-2322-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd74/8895191/7588dca825c0/WJCC-10-2322-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd74/8895191/c0005c184a08/WJCC-10-2322-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd74/8895191/b60ccdf0b598/WJCC-10-2322-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd74/8895191/00543463379d/WJCC-10-2322-g005.jpg

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Synchronous Gall Bladder and Bile Duct Cancer: A Short Series of Seven Cases and a Brief Review of Literature.同步性胆囊和胆管癌：七例简短病例系列及文献简要综述
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