Torres-Mendoza Daniel, Ortega Humberto E, Cubilla-Rios Luis
Laboratory of Tropical Bioorganic Chemistry, Faculty of Natural, Exact Sciences and Technology, University of Panama, Panama 0824, Panama.
Vicerrectoría de Investigación y Postgrado, University of Panama, Panama 0824, Panama.
J Fungi (Basel). 2020 May 1;6(2):58. doi: 10.3390/jof6020058.
Endophytic fungi are an important group of microorganisms and one of the least studied. They enhance their host's resistance against abiotic stress, disease, insects, pathogens and mammalian herbivores by producing secondary metabolites with a wide spectrum of biological activity. Therefore, they could be an alternative source of secondary metabolites for applications in medicine, pharmacy and agriculture. In this review, we analyzed patents related to the production of secondary metabolites and biotransformation processes through endophytic fungi and their fields of application. We examined 245 patents (224 related to secondary metabolite production and 21 for biotransformation). The most patented fungi in the development of these applications belong to the , , , , and genera and cover uses in the biomedicine, agriculture, food, and biotechnology industries.
内生真菌是一类重要的微生物，也是研究最少的微生物之一。它们通过产生具有广泛生物活性的次生代谢产物，增强宿主对非生物胁迫、疾病、昆虫、病原体和哺乳动物食草动物的抗性。因此，它们可能是用于医药、制药和农业的次生代谢产物的替代来源。在本综述中，我们分析了与内生真菌产生次生代谢产物和生物转化过程及其应用领域相关的专利。我们审查了245项专利（224项与次生代谢产物生产相关，21项与生物转化相关）。在这些应用开发中获得专利最多的真菌属于曲霉属、青霉属、链格孢属、镰刀菌属和木霉属，涵盖了生物医药、农业、食品和生物技术行业的用途。
