Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Mult Scler Relat Disord. 2020 Jul;42:102148. doi: 10.1016/j.msard.2020.102148. Epub 2020 Apr 28.
Clinician-assessed Expanded Disease Status Scale (EDSS) is gold standard in clinical investigations but normally unavailable in population-based, patient-centred MS-studies. Our objective was to develop a self-reported gait measure reflecting EDSS-categories.
We developed the self-reported disability status scale (SRDSS) with three categories (≤3.5, 4-6.5, ≥7) based on three mobility-related questions. The SRDSS was determined for 173 persons with MS and validated against clinical EDSS to calculate sensitivity and specificity.
Accuracy was 88.4% (153 correctly classified) and weighted kappa 0.73 (0.62-0.84). Sensitivity/specificity-pairs were 94.5%/77.8%, 69.0%/94.7% and 100%/98.2% for SRDSS ≤3.5, 4-6.5 and ≥7, respectively.
Self-reported SRDSS approximates EDSS-categories well and fosters comparability between clinical and population-based studies.
临床评估扩展疾病状况量表（EDSS）是临床研究的金标准，但在基于人群、以患者为中心的多发性硬化症研究中通常无法获得。我们的目的是开发一种反映 EDSS 类别的自我报告步态测量方法。
我们基于三个与移动性相关的问题，制定了三个类别（≤3.5、4-6.5、≥7）的自我报告残疾状况量表（SRDSS）。对 173 名多发性硬化症患者进行了 SRDSS 测定，并与临床 EDSS 进行了验证，以计算敏感性和特异性。
准确性为 88.4%（153 例正确分类），加权kappa 值为 0.73（0.62-0.84）。SRDSS≤3.5、4-6.5 和≥7 的敏感性/特异性分别为 94.5%/77.8%、69.0%/94.7%和 100%/98.2%。
自我报告的 SRDSS 很好地近似 EDSS 类别，并促进了临床研究和基于人群的研究之间的可比性。
