自评残疾状况量表（SRDSS）的编制与验证，旨在评估 EDSS 类别。
Development and validation of the self-reported disability status scale (SRDSS) to estimate EDSS-categories.
机构信息
Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
出版信息
Mult Scler Relat Disord. 2020 Jul;42:102148. doi: 10.1016/j.msard.2020.102148. Epub 2020 Apr 28.
BACKGROUND
Clinician-assessed Expanded Disease Status Scale (EDSS) is gold standard in clinical investigations but normally unavailable in population-based, patient-centred MS-studies. Our objective was to develop a self-reported gait measure reflecting EDSS-categories.
METHODS
We developed the self-reported disability status scale (SRDSS) with three categories (≤3.5, 4-6.5, ≥7) based on three mobility-related questions. The SRDSS was determined for 173 persons with MS and validated against clinical EDSS to calculate sensitivity and specificity.
RESULTS
Accuracy was 88.4% (153 correctly classified) and weighted kappa 0.73 (0.62-0.84). Sensitivity/specificity-pairs were 94.5%/77.8%, 69.0%/94.7% and 100%/98.2% for SRDSS ≤3.5, 4-6.5 and ≥7, respectively.
CONCLUSIONS
Self-reported SRDSS approximates EDSS-categories well and fosters comparability between clinical and population-based studies.
背景
临床评估扩展疾病状况量表（EDSS）是临床研究的金标准，但在基于人群、以患者为中心的多发性硬化症研究中通常无法获得。我们的目的是开发一种反映 EDSS 类别的自我报告步态测量方法。
方法
我们基于三个与移动性相关的问题，制定了三个类别（≤3.5、4-6.5、≥7）的自我报告残疾状况量表（SRDSS）。对 173 名多发性硬化症患者进行了 SRDSS 测定，并与临床 EDSS 进行了验证，以计算敏感性和特异性。
结果
准确性为 88.4%（153 例正确分类），加权kappa 值为 0.73（0.62-0.84）。SRDSS≤3.5、4-6.5 和≥7 的敏感性/特异性分别为 94.5%/77.8%、69.0%/94.7%和 100%/98.2%。
结论
自我报告的 SRDSS 很好地近似 EDSS 类别，并促进了临床研究和基于人群的研究之间的可比性。
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