McGuigan C, Hutchinson M
Department of Neurology, University College Dublin and St Vincent's University Hospital, Dublin, Ireland.
J Neurol Neurosurg Psychiatry. 2004 Feb;75(2):266-9.
The aim of this study was to assess the psychometric properties of the Multiple Sclerosis Impact Scale (MSIS-29) for patients in the community and in a hospital setting.
During an epidemiological study, 172 people with multiple sclerosis (MS) were examined and completed the MSIS-29, the London Handicap Scale, and Beck's Depression Inventory; disability was assessed by the Kurtzke Expanded Disability Status Score (EDSS) and the Multiple Sclerosis Functional Composite. At the hospital neurology clinic, 102 MS patients completed the MSIS-29 and EDSS assessments were performed; 41 of these patients had repeat evaluations six months later. The psychometric properties of the MSIS-29 were examined.
In the 172 community and the 102 hospital patients the psychometric properties of the MSIS-29 were satisfactory, with high convergent and low divergent validity. It was significantly responsive to change in the contexts of self-reported change (p<0.034) and EDSS worsening (p<0.001). The MSIS-29 physical score did not change over time when the EDSS was stable, and increased significantly in proportion to EDSS deterioration (p = 0.014).
The psychometric properties of the MSIS-29 are acceptable; it is a valuable outcome measure in intervention studies of patients with MS.
本研究旨在评估社区和医院环境中多发性硬化症患者的多发性硬化症影响量表（MSIS - 29）的心理测量特性。
在一项流行病学研究中，对172名多发性硬化症（MS）患者进行了检查，并让他们完成了MSIS - 29、伦敦残疾量表和贝克抑郁量表；通过库茨克扩展残疾状态评分（EDSS）和多发性硬化症功能综合评分来评估残疾情况。在医院神经科门诊，102名MS患者完成了MSIS - 29评估并进行了EDSS评估；其中41名患者在6个月后进行了重复评估。对MSIS - 29的心理测量特性进行了检查。
在172名社区患者和102名医院患者中，MSIS - 29的心理测量特性令人满意，具有高收敛效度和低发散效度。在自我报告的变化（p < 0.034）和EDSS恶化（p < 0.001）的情况下，它对变化有显著反应。当EDSS稳定时，MSIS - 29身体评分随时间没有变化，并且与EDSS恶化成比例显著增加（p = 0.014）。
MSIS - 29的心理测量特性是可接受的；它是MS患者干预研究中有价值的结果指标。
