意外发现：益生菌给药大大加剧了全氟丁烷磺酸对斑马鱼的生殖毒性。
Unexpected Observations: Probiotic Administration Greatly Aggravates the Reproductive Toxicity of Perfluorobutanesulfonate in Zebrafish.
机构信息
State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
出版信息
Chem Res Toxicol. 2020 Jul 20;33(7):1605-1608. doi: 10.1021/acs.chemrestox.0c00139. Epub 2020 May 8.
The present study exposed adult zebrafish to 0, 10, and 100 μg/L perfluorobutanesulfonate (PFBS) with or without dietary supplement of probiotic . Interaction between probiotic and PFBS on sex endocrine and reproduction was investigated. It was striking to find that PFBS and probiotic coexposures almost ceased the fecundity, which was accompanied by disturbances in sex hormones and oocyte maturation in females. In contrast, probiotic additive efficiently antagonized the estrogenic activity of PFBS in males. For the first time, this study reported that probiotic heavily depended on sex to modulate the endocrine disruption and reproductive toxicity of aquatic pollutants.
本研究将成年斑马鱼暴露于 0、10 和 100μg/L 的全氟丁烷磺酸（PFBS）中，并在有或没有益生菌膳食补充的情况下进行。研究了益生菌和 PFBS 对性别内分泌和生殖的相互作用。令人惊讶的是，PFBS 和益生菌的共同暴露几乎完全停止了雌性的生殖能力，同时伴随着性激素和卵母细胞成熟的紊乱。相比之下，益生菌添加剂有效地拮抗了 PFBS 对雄性的雌激素活性。本研究首次报道，益生菌严重依赖于性别来调节水生污染物的内分泌干扰和生殖毒性。
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