National Institutes of Health , Bethesda, MD, USA.
Cheongju University , Cheongju, Republic of Korea.
Dev Neurorehabil. 2021 Jan;24(1):8-17. doi: 10.1080/17518423.2020.1756005. Epub 2020 May 6.
Rehabilitation in cerebral palsy (CP) seeks to harness neuroplasticity to improve movement, including walking, yet cortical activation underlying gait is not well understood. We used electroencephalography (EEG) to compare motor related cortical activity, measured by mu rhythm, during quiet standing and treadmill walking in 10 children with unilateral CP and 10 age- and sex-matched children with typical development (TD). Peak mu band frequency, mu rhythm desynchronization (MRD), and gait related intra- and inter-hemispheric coherence were examined. MRD during walking was observed bilaterally over motor cortex in both cohorts but peak mu band frequency showing MRD was significantly lower in CP compared to TD. Coherence during quiet standing between motor and frontal regions was significantly higher in the non-dominant compared to dominant hemisphere in CP with no hemispheric differences in TD. EEG-based measures should be further investigated as clinical biomarkers for atypical motor development and to assess rehabilitation effectiveness.
脑性瘫痪（CP）的康复旨在利用神经可塑性来改善运动，包括行走，但步态的皮质激活尚不清楚。我们使用脑电图（EEG）比较了 10 名单侧 CP 儿童和 10 名年龄和性别匹配的典型发育（TD）儿童在安静站立和跑步机行走期间的运动相关皮质活动，通过 mu 节律测量。检查了峰值 mu 频带频率、mu 节律去同步化（MRD）以及与步态相关的半球内和半球间相干性。在两个队列中，行走时均在运动皮质的双侧观察到 MRD，但 CP 中显示 MRD 的峰值 mu 频带频率明显低于 TD。在 CP 中，与优势半球相比，非优势半球的运动和额区在安静站立期间的相干性显著更高，而 TD 中则没有半球差异。基于 EEG 的测量值应作为非典型运动发育的临床生物标志物进一步研究，并评估康复效果。
