Rodney Cady, Rodney Sherriann, Millis Richard M
Departments of Clinical Medicine and Pathophysiology, American University of Antigua College of Medicine, Antigua and Barbuda.
Autoimmune Dis. 2020 Jan 19;2020:8718736. doi: 10.1155/2020/8718736. eCollection 2020.
Vitamin D deficiency is prevalent in all ages regardless of climate or geographical location and evidence is emerging that the incidence of autoimmune diseases is increasing worldwide. Women make up a large proportion of autoimmune disease diagnoses, underscoring the importance of fully elucidating the complex synergistic relationships between estrogens and vitamin D. Vitamin D receptor-activating drugs appear to enhance remyelination in patients diagnosed with multiple sclerosis (MS) and other demyelinating diseases such as neuromyelitis optica (NMO). This review is intended to update health practitioners about the potential role of vitamin D deficiency demyelination and to motivate future research on dietary recommendations for vitamin D in preventing and treating demyel1nating diseases.
无论气候或地理位置如何，维生素D缺乏在所有年龄段都很普遍，而且有证据表明自身免疫性疾病的发病率在全球范围内都在上升。自身免疫性疾病诊断中有很大比例是女性，这凸显了充分阐明雌激素与维生素D之间复杂协同关系的重要性。维生素D受体激活药物似乎能增强被诊断患有多发性硬化症（MS）和其他脱髓鞘疾病（如视神经脊髓炎（NMO））患者的髓鞘再生。这篇综述旨在向医疗从业者介绍维生素D缺乏与脱髓鞘的潜在关系，并推动未来关于维生素D饮食建议在预防和治疗脱髓鞘疾病方面的研究。
