Guo Jiaocen, Kong Fandong, Ma Qingyun, Xie Qingyi, Zhang Renshuai, Dai Haofu, Wu Yougen, Zhao Youxing
Hainan Key Laboratory for Research and Development of Natural Product From Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou, China.
College of Horticulture, Hainan University, Haikou, China.
Front Chem. 2020 Apr 16;8:279. doi: 10.3389/fchem.2020.00279. eCollection 2020.
fungi have long been used as functional foods and traditional medicines in Asian countries. is one of the main species of fungi distributed in Hainan province of China, the fruiting bodies of which have been used in folk to lower blood sugar for a long time. A chemical investigation of the fruiting bodies of led to the isolation of seven new meroterpenoids, named ganoduriporols F-L . The chemical structures of the compounds were elucidated by spectroscopic data including HRESIMS and 2D NMR. Compounds represent the first examples of ganoduriporol-type meroterpenoids bearing oxepane rings in their skeletons. Compounds showed inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) comparable to the positive control NaVO, with IC values of 17, 20, 19, and 23 μM, respectively.
在亚洲国家，真菌长期以来一直被用作功能性食品和传统药物。 是分布于中国海南省的主要真菌种类之一，其子实体在民间长期用于降血糖。对 的子实体进行化学研究，分离出了七种新的杂萜类化合物，命名为ganoduriporols F-L 。通过包括高分辨电喷雾电离质谱（HRESIMS）和二维核磁共振（2D NMR）在内的光谱数据阐明了这些化合物的化学结构。化合物 是骨架中带有氧杂环庚烷环的ganoduriporol型杂萜类化合物的首个实例。化合物 对蛋白酪氨酸磷酸酶1B（PTP1B）表现出与阳性对照偏钒酸钠相当的抑制活性，IC值分别为17、20、19和23 μM。
