Bakula Daniela, Scheibye-Knudsen Morten
Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
Front Cell Dev Biol. 2020 Apr 15;8:239. doi: 10.3389/fcell.2020.00239. eCollection 2020.
Maintaining mitochondrial health is emerging as a keystone in aging and associated diseases. The selective degradation of mitochondria by mitophagy is of particular importance in keeping a pristine mitochondrial pool. Indeed, inherited monogenic diseases with defects in mitophagy display complex multisystem pathologies but particularly progressive neurodegeneration. Fortunately, therapies are being developed that target mitophagy allowing new hope for treatments for previously incurable diseases. Herein, we describe mitophagy and associated diseases, coin the term mitophaging and describe new small molecule interventions that target different steps in the mitophagic pathway. Consequently, several age-associated diseases may be treated by targeting mitophagy.
维持线粒体健康正逐渐成为衰老及相关疾病的关键所在。线粒体自噬对线粒体的选择性降解在维持纯净的线粒体库方面尤为重要。事实上，线粒体自噬存在缺陷的遗传性单基因疾病表现出复杂的多系统病变，尤其是进行性神经退行性变。幸运的是，目前正在开发针对线粒体自噬的疗法，为治疗以前无法治愈的疾病带来了新希望。在此，我们描述线粒体自噬及相关疾病，创造“mitophaging”一词，并描述针对线粒体自噬途径不同步骤的新型小分子干预措施。因此，通过靶向线粒体自噬可能治疗多种与年龄相关的疾病。
