Emergency Department, Tianjin 4th Center Hospital, No.1 Zhongshan Road, Hebei District, Tianjin 300142, China.
J Comp Eff Res. 2020 May;9(7):459-468. doi: 10.2217/cer-2019-0202. Epub 2020 May 6.
To assess the immunogenicity and safety of rabies vaccination under the Zagreb and Essen regimens by performing a meta-analysis. Electronic databases were searched for eligible studies. Risk ratios and weighted mean differences with 95% CIs were used to calculate estimates. A total of 18 studies were included. Rabies virus neutralizing antibody concentration was comparable between the two regimens at D7 and 14. No significant differences were observed in seroconversion rates from D14 and 42. Incidence of fever was higher in Zagreb group (risk ratio: 1.55 [1.37-1.76]); but no significant differences were present for other common adverse events. Rabies vaccination under the Zagreb regimen was noninferior to the Essen regimen in immunogenicity and had an acceptable safety profile.
采用荟萃分析评估萨格勒布和埃森方案下狂犬病疫苗接种的免疫原性和安全性。电子数据库中检索符合条件的研究。使用风险比和加权均数差及其 95%置信区间计算评估结果。共纳入 18 项研究。两种方案在第 7 天和 14 天的狂犬病病毒中和抗体浓度相当。从第 14 天和第 42 天的血清转化率没有观察到显著差异。发热发生率在萨格勒布组较高（风险比：1.55 [1.37-1.76]）；但其他常见不良事件无显著差异。萨格勒布方案下的狂犬病疫苗接种在免疫原性方面不劣于埃森方案，且具有可接受的安全性特征。
