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鉴定核非编码RNA觉醒基因（kakusei）作为蜜蜂的即刻早期基因及其在神经行为学研究中的应用。

Identification of kakusei, a nuclear non-coding RNA, as an immediate early gene from the honeybee, and its application for neuroethological study.

作者信息

Kiya Taketoshi, Ugajin Atsushi, Kunieda Takekazu, Kubo Takeo

机构信息

Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan.

出版信息

Int J Mol Sci. 2012 Nov 22;13(12):15496-509. doi: 10.3390/ijms131215496.

DOI:10.3390/ijms131215496
PMID:23443077
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3546645/
Abstract

The honeybee is a social insect that exhibits various social behaviors. To elucidate the neural basis of honeybee behavior, we detected neural activity in freely-moving honeybee workers using an immediate early gene (IEG) that is expressed in a neural activity-dependent manner. In European honeybees (Apis mellifera), we identified a novel nuclear non-coding RNA, termed kakusei, as the first insect IEG, and revealed the neural activity pattern in foragers. In addition, we isolated a homologue of kakusei, termed Acks, from the Japanese honeybee (Apis cerana), and detected active neurons in workers fighting with the giant hornet.

摘要

蜜蜂是一种表现出各种社会行为的群居昆虫。为了阐明蜜蜂行为的神经基础，我们使用一种以神经活动依赖方式表达的即早基因（IEG），检测了自由活动的工蜂的神经活动。在欧洲蜜蜂（西方蜜蜂）中，我们鉴定出一种名为觉醒（kakusei）的新型核非编码RNA，作为首个昆虫IEG，并揭示了觅食工蜂的神经活动模式。此外，我们从日本蜜蜂（东方蜜蜂）中分离出觉醒（kakusei）的同源物，称为Acks，并检测了与大黄蜂战斗的工蜂中的活跃神经元。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c9e/3546645/9c66fa389632/ijms-13-15496f6.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c9e/3546645/476d12b65069/ijms-13-15496f2.jpg
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