Khan Haseeb A, Sobki Samia H, Ekhzaimy Aishah, Khan Isra, Almusawi Mona A
Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Department of Central Military Laboratory and Blood Bank, Prince Sultan Military Medical City, Riyadh 11159, Saudi Arabia.
Saudi J Biol Sci. 2018 Dec;25(8):1729-1732. doi: 10.1016/j.sjbs.2018.05.027. Epub 2018 Jun 1.
Insulin resistance is a hallmark feature of type-2 diabetes mellitus (T2DM). We determined the homeostatic model assessment insulin resistance (HOMA-IR) and evaluated its association with C-peptide, insulin, fasting blood glucose (FBG) and glycated hemoglobin (HbA1c) in T2DM patients and non-diabetic subjects. This study comprised a total of 47 T2DM patients and 38 non-diabetic controls. Venous blood samples from all the subjects were collected and sera were analyzed for FBG, HbA1c, insulin and C-peptide using an autoanalyzer. HOMA-IR was calculated using the following equation: HOMA-IR = fasting insulin (µU/ml) × fasting glucose (mmol/L)/22.5. There was a significant increase in the levels of FBG and HbA1c in diabetic patients. Although the levels of C-peptide and insulin did not differ significantly between the two groups, a significant increase in HOMA-IR was observed in T2DM patients. Both insulin and C-peptide were significantly correlated with HOMA-IR. In conclusion, C-peptide may serve as a simple and convenient predictor of HOMA-IR.
胰岛素抵抗是2型糖尿病（T2DM）的一个标志性特征。我们测定了稳态模型评估胰岛素抵抗（HOMA-IR），并评估了其与T2DM患者和非糖尿病受试者的C肽、胰岛素、空腹血糖（FBG）及糖化血红蛋白（HbA1c）之间的关联。本研究共纳入47例T2DM患者和38例非糖尿病对照。采集所有受试者的静脉血样本，使用自动分析仪分析血清中的FBG、HbA1c、胰岛素和C肽。HOMA-IR使用以下公式计算：HOMA-IR = 空腹胰岛素（µU/ml）×空腹血糖（mmol/L）/22.5。糖尿病患者的FBG和HbA1c水平显著升高。虽然两组之间的C肽和胰岛素水平无显著差异，但T2DM患者的HOMA-IR显著升高。胰岛素和C肽均与HOMA-IR显著相关。总之，C肽可能作为HOMA-IR的一个简单便捷的预测指标。
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