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生长分化因子15在肾脏供体和受体中的预后价值

Prognostic Value of Growth Differentiation Factor 15 in Kidney Donors and Recipients.

作者信息

Jehn Ulrich, Schütte-Nütgen Katharina, Henke Ute, Bautz Joachim, Pavenstädt Hermann, Suwelack Barbara, Reuter Stefan

机构信息

Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Münster, 48149 Münster, Germany.

出版信息

J Clin Med. 2020 May 3;9(5):1333. doi: 10.3390/jcm9051333.

DOI:10.3390/jcm9051333
PMID:32375259
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7291214/
Abstract

Growth differentiation factor-15 (GDF15) is associated with inflammatory conditions, chronic kidney disease, cardiovascular disease and mortality. There is very limited data on GDF15 after kidney donation and transplantation. We analyzed serum samples of patients who donated a kidney (54 living donors) or who underwent kidney transplantation (104 recipients) at the University Hospital of Münster (Germany) between 2013 and 2015, for GDF15 levels immediately prior and one year after surgery. GDF15 levels were significantly elevated in end-stage renal disease patients compared to healthy individuals (2844 (IQR 2087, 3361) pg/ml vs. 384 (IQR 307, 487) pg/ml, < 0.001). GDF15 was strongly associated with the dialysis vintage. While kidney transplantation led to a significant decrease of GDF15 (913 (IQR 674, 1453) pg/ml, < 0.001), kidney donation caused a moderate increase of GDF15 (510 (IQR 420, 626), < 0.001) one year after surgery. GDF15 levels remained significantly higher in recipients and kidney donors than in healthy controls (735 (IQR 536, 1202) pg/ml vs. 384 (IQR 307, 487) pg/ml, < 0.001). GDF15 is increased in patients with kidney disease and is associated with dialysis vintage. Given its decrease after transplantation and its increase after uni-nephrectomy, GDF15 might be a marker of kidney function. However, since it correlates only to the eGFR in transplanted patients it may indicate chronic kidney disease.

摘要

生长分化因子-15（GDF15）与炎症性疾病、慢性肾病、心血管疾病及死亡率相关。关于肾捐赠和移植后GDF15的数据非常有限。我们分析了2013年至2015年间在德国明斯特大学医院捐赠肾脏的患者（54名活体供体）或接受肾脏移植的患者（104名受者）的血清样本，检测手术前即刻及术后一年的GDF15水平。与健康个体相比，终末期肾病患者的GDF15水平显著升高（2844（四分位间距2087，3361）pg/ml 对 384（四分位间距307，487）pg/ml，<0.001）。GDF15与透析时间密切相关。肾脏移植导致GDF15显著下降（913（四分位间距674，1453）pg/ml，<0.001），而肾捐赠导致术后一年GDF15适度升高（510（四分位间距420，626），<0.001）。受者和肾捐赠者的GDF15水平仍显著高于健康对照（735（四分位间距536，1202）pg/ml 对 384（四分位间距307，487）pg/ml，<0.001）。肾病患者的GDF15升高且与透析时间相关。鉴于其在移植后下降及单侧肾切除后升高，GDF15可能是肾功能的一个标志物。然而，由于它仅与移植患者的估算肾小球滤过率（eGFR）相关，它可能提示慢性肾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3d2/7291214/4b5040d82490/jcm-09-01333-g007.jpg
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Growth Differentiation Factor 15 in Children with Chronic Kidney Disease and after Renal Transplantation.生长分化因子 15 在慢性肾脏病儿童及肾移植后的变化。
Dis Markers. 2020 Feb 6;2020:6162892. doi: 10.1155/2020/6162892. eCollection 2020.
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Renoprotective and Immunomodulatory Effects of GDF15 following AKI Invoked by Ischemia-Reperfusion Injury.缺血再灌注损伤诱导的急性肾损伤后 GDF15 的肾保护和免疫调节作用。
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Cytomegalovirus Viremia after Living and Deceased Donation in Kidney Transplantation.
老年人身体活动、生长分化因子15与体重之间的关联：一项纵向中介分析。
J Cachexia Sarcopenia Muscle. 2023 Jan 20;14(2):771-80. doi: 10.1002/jcsm.13152.
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NCAM1 and GDF15 are biomarkers of Charcot-Marie-Tooth disease in patients and mice.神经细胞黏附分子 1 和生长分化因子 15 是患者和小鼠中的夏科-马里-图什病的生物标志物。
Brain. 2022 Nov 21;145(11):3999-4015. doi: 10.1093/brain/awac055.
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A Growth Differentiation Factor 15-Based Risk Score Model to Predict Mortality in Hemodialysis Patients.一种基于生长分化因子15的风险评分模型，用于预测血液透析患者的死亡率。
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