昆虫提取物对非酒精性脂肪性肝病的有益作用。
Beneficial Effects of Insect Extracts on Nonalcoholic Fatty Liver Disease.
机构信息
Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, Korea.
University of Science and Technology (UST), Korean Medicine Life Science, Daejeon Korea.
出版信息
J Med Food. 2020 Jul;23(7):760-771. doi: 10.1089/jmf.2019.4536. Epub 2020 May 7.
It is well known that nonalcoholic fatty liver disease (NAFLD) is a common disease worldwide because of unhealthy changes in dietary habits. In this study, we determined the effects of Linnaeus, 1758 extract (TML) and Linnaeus, 1771 larvae extract (ADL) in cellular and animal models. , TML and ADL treatments did not cause cytotoxicity, but attenuated the accumulation of lipid in HepG2 cells induced by free fatty acids. , mice were orally treated with TML and ADL for 10 weeks during high-fat diet feeding. TML and ADL administration significantly reduced the weight of body, liver tissue, and adipose tissue. Serum lipid profiles, hepatic functional parameters, and glucose levels were ameliorated by TML and ADL. Moreover, TML and ADL suppressed increased lipogenesis and inflammation-related makers, and improved antioxidant enzyme activity. In liver tissue, the decreased lipid accumulation by administration of TML and ADL was observed using Oil Red O and Hematoxylin and Eosin staining. Therefore, we suggest that TML and ADL may be having a therapeutic potential and is used to develop a therapeutic agent for NAFLD.
众所周知，由于饮食习惯的不健康变化，非酒精性脂肪性肝病（NAFLD）是一种全球范围内的常见疾病。在这项研究中，我们确定了 Linnaeus, 1758 提取物（TML）和 Linnaeus, 1771 幼虫提取物（ADL）在细胞和动物模型中的作用。结果表明，TML 和 ADL 处理不会引起细胞毒性，但可以减轻游离脂肪酸诱导的 HepG2 细胞中脂质的积累。进一步的研究表明，在高脂肪饮食喂养期间，用 TML 和 ADL 对小鼠进行 10 周的口服治疗。TML 和 ADL 给药显著减轻了体重、肝组织和脂肪组织的重量。TML 和 ADL 改善了血清脂质谱、肝功能参数和血糖水平。此外，TML 和 ADL 抑制了脂肪生成和炎症相关标志物的增加，并提高了抗氧化酶的活性。在肝组织中，通过 TML 和 ADL 的给药观察到脂质积累的减少，使用油红 O 和苏木精和伊红染色。因此，我们认为 TML 和 ADL 可能具有治疗潜力，并可用于开发治疗 NAFLD 的药物。
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