Biomedical Ethics Research Program, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA.
Department of Obstetrics & Gynecology, Mayo Clinic, Rochester, MN, USA.
J Racial Ethn Health Disparities. 2021 Feb;8(1):69-79. doi: 10.1007/s40615-020-00757-z. Epub 2020 May 7.
The USA is one of the few countries in the world in which maternal and infant morbidity and mortality continue to increase, with the greatest disparities observed among non-Hispanic Black women and their infants. Traditional explanations for disparate outcomes, such as personal health behaviors, socioeconomic status, health literacy, and access to healthcare, do not sufficiently explain why non-Hispanic Black women continue to die at three to four times the rate of White women during pregnancy, childbirth, or postpartum. One theory gaining prominence to explain the magnitude of this disparity is allostatic load or the cumulative physiological effects of stress over the life course. People of color disproportionally experience social, structural, and environmental stressors that are frequently the product of historic and present-day racism. In this essay, we present the growing body of evidence implicating the role of elevated allostatic load in adverse pregnancy outcomes among women of color. We argue that there is a moral imperative to assign additional resources to reduce the effects of elevated allostatic load before, during, and after pregnancy to improve the health of women and their children.
美国是世界上少数几个孕产妇发病率和死亡率仍在持续上升的国家之一,其中非西班牙裔黑人妇女及其婴儿的差异最大。传统的解释差异结果的因素,如个人健康行为、社会经济地位、健康素养和获得医疗保健的机会等,不能充分解释为什么非西班牙裔黑人妇女在怀孕期间、分娩期间或产后的死亡率仍是非裔美国白人妇女的三到四倍。一种解释这种差异幅度的理论正在兴起,即适应负荷或压力在整个生命过程中对生理产生的累积影响。有色人种不成比例地经历社会、结构和环境压力源,这些压力源往往是历史和当今种族主义的产物。在这篇文章中,我们提出了越来越多的证据,表明升高的适应负荷在有色人种妇女不良妊娠结局中的作用。我们认为,有必要在怀孕前、怀孕期间和怀孕后分配额外的资源来减少升高的适应负荷的影响,以改善妇女及其子女的健康。