Mosmann J P, Zayas S, Kiguen A X, Venezuela R F, Rosato O, Cuffini C G
Facultad de Ciencias Médicas, Instituto de Virología "Dr. J. M. Vanella", Universidad Nacional de Córdoba, Enfermera Gordillo Gómez s/n- Ciudad Universitaria, ZP: 5016, Córdoba, Argentina.
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
BMC Infect Dis. 2021 May 5;21(1):422. doi: 10.1186/s12879-021-06118-3.
HPV and C.trachomatis are the most prevalent, viral and bacterial STI worldwide. Both commonly have an asymptomatic development and can evolve into a persistent infection which, added to coinfections, may be important cofactors for the oncogenic transformation.
Evaluate the prevalence of oral and genital HPV and C.trachomatis infection in women with normal and abnormal cervical cytology.
The cross-sectional study included 200 swabs, 100 oral and 100 cervical from 50 women with normal and 50 with abnormal cervical cytology. HPV and C.trachomatis infections were detected using PCR with specific primers.
HPV DNA was detected in 27% (n = 27/100) of women with normal and abnormal cytology. Out of 100 genital samples we detected HPV DNA in 18% (n = 18/100) and 14% (n = 14/100) out of 100 oral samples. HPV genotypes detected were genotype 6 of low-risk and 16, 31, 52, 58 and 16-31 coinfection of high-risk. C.trachomatis DNA was detected in 49% (n = 49/100) of patients. Out of 100 genital samples we detected C.trachomatis in 35% (n = 35/100) and 31% (n = 31) out of 100 oral samples. There is statistically significant (p < 0.05) between cytology and HPV and C.trachomatis infection but there is no statistically significant between cytology and the other characteristics.
Since the histology of oral mucosa resembles that of the uterine cervix, we can anticipate the presence of HPV and other STI which are detected in different lesions of genital areas and the oral mucosa. Therefore, is important C.trachomatis detection and specific treatment in asymptomatic women because this infection may increase the risk of HPV persistence and coinfection induces a pro-inflammatory environment that may promote the carcinogenesis.
人乳头瘤病毒（HPV）和沙眼衣原体是全球最常见的病毒性和细菌性性传播感染。两者通常无症状发展，并可演变为持续性感染，加上合并感染，可能是致癌转化的重要辅助因素。
评估宫颈细胞学正常和异常的女性口腔和生殖道HPV及沙眼衣原体感染的患病率。
这项横断面研究纳入了200份拭子，其中100份取自口腔，100份取自宫颈，来自50名宫颈细胞学正常和50名宫颈细胞学异常的女性。使用特异性引物通过聚合酶链反应（PCR）检测HPV和沙眼衣原体感染。
宫颈细胞学正常和异常的女性中，27%（n = 27/100）检测到HPV DNA。在100份生殖道样本中，18%（n = 18/100）检测到HPV DNA，在100份口腔样本中，14%（n = 14/100）检测到HPV DNA。检测到的HPV基因型为低风险的6型以及高风险的16、31、52、58型和16 - 31型合并感染。49%（n = 49/100）的患者检测到沙眼衣原体DNA。在100份生殖道样本中，35%（n = 35/100）检测到沙眼衣原体，在100份口腔样本中，31%（n = 31）检测到沙眼衣原体。细胞学与HPV及沙眼衣原体感染之间存在统计学显著差异（p < 0.05），但细胞学与其他特征之间无统计学显著差异。
由于口腔黏膜的组织学与子宫颈相似，我们可以预期在生殖道和口腔黏膜的不同病变中会存在HPV和其他性传播感染。因此，对无症状女性进行沙眼衣原体检测和特异性治疗很重要，因为这种感染可能会增加HPV持续感染的风险，合并感染会诱导促炎环境，可能促进致癌作用。
