Department of Nuclear Medicine, Faculty of Medicine, Trakya University, Edirne, Turkey.
Curr Radiopharm. 2021;14(1):5-14. doi: 10.2174/1874471013666200508080250.
Breast cancer is the leading cause of cancer in women. 13% of breast cancer patients are at a distant stage and mortality is due to metastases rather than primary disease. The unique genetic structure and natural process of breast cancer make it a very suitable area for targeted therapies. Experimental tumor models are validated methods to examine the pathogenesis of cancer, the onset of the neoplastic process and progression.
This study aims to review the current literature on experimental breast cancer models and to bring a new perspective to the use of these models in teranostic preclinical studies in terms of the imaging.
Search for relevant literature from academic databases using keywords (Breast cancer, theranostic, preclinical imaging, tumor models, animal study, and tailored therapy) was conducted. The full text of the articles was reached and reviewed. Current scientific data has been reevaluated and compiled according to subtitles.
The development of animal models for breast cancer research has been done in the last century. Imaging methods used in breast cancer are used for tumor localization, quantification of tumor mass, imaging of genes and proteins, evaluation of tumor microenvironment, evaluation of tumor cell proliferation and metabolism and treatment response evaluation. Since human breast cancer is a heterogeneous group of diseases in terms of genetics and phenotype; it is not possible for a single model to adequately address all aspects of breast cancer biology. Considering that each model has advantages and disadvantages, the most suitable model should be chosen to verify the thesis of the study.
乳腺癌是女性癌症的主要病因。13%的乳腺癌患者处于晚期，其死亡率是由转移而不是原发性疾病引起的。乳腺癌独特的遗传结构和自然病程使其成为靶向治疗的非常合适的领域。实验性肿瘤模型是验证癌症发病机制、肿瘤发生和进展的方法。
本研究旨在回顾目前关于实验性乳腺癌模型的文献，并从影像学角度为这些模型在治疗前临床研究中的应用带来新的视角。
使用关键词（乳腺癌、治疗诊断、临床前影像学、肿瘤模型、动物研究和靶向治疗）在学术数据库中搜索相关文献。获取并回顾文章的全文。根据副标题重新评估和编译当前的科学数据。
在过去的几十年中，已经为乳腺癌研究开发了动物模型。用于乳腺癌的成像方法用于肿瘤定位、肿瘤质量定量、基因和蛋白质成像、肿瘤微环境评估、肿瘤细胞增殖和代谢评估以及治疗反应评估。由于人类乳腺癌在遗传和表型方面是一组异质性疾病，因此单一模型不可能充分解决乳腺癌生物学的所有方面。鉴于每种模型都有其优缺点，应选择最合适的模型来验证研究的假设。
