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长链非编码 RNA ACTA2-AS1 预测三阴性乳腺癌的恶性程度和预后不良，并通过调节 miR-532-5p 来调节肿瘤进展。

lncRNA ACTA2-AS1 predicts malignancy and poor prognosis of triple-negative breast cancer and regulates tumor progression via modulating miR-532-5p.

机构信息

Department of Breast Surgery, Fujian Provincial Maternity and Children's Hospital, 18 Dao Shan Road, Gulou District, Fuzhou, 350001, China.

出版信息

BMC Mol Cell Biol. 2022 Jul 27;23(1):34. doi: 10.1186/s12860-022-00432-7.

DOI:10.1186/s12860-022-00432-7
PMID:35896973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9327331/
Abstract

BACKGROUND

Dysregulation of ACTA2-AS1 and miR-532-5p and their functions in various cancers have been widely reported. Their potential of serving as biomarkers in triple-negative breast cancer (TNBC) remains unknown. This study aimed to evaluate the function of ACTA2-AS1 and miR-532-5p and their potential of serving as biomarkers in TNBC.

RESULTS

The TNBC tissues were collected from 119 patients, where the reduced level of ACTA2-AS1 and increased level of miR-532-5p were observed by PCR and showed a significantly negative correlation (P <  0.001). Both ACTA2-AS1 and miR-532-5p were closely associated with the malignant development and poor prognosis of TNBC patients. Moreover, in TNBC cell, overexpressing ACTA2-AS1 was found to suppress cell proliferation and metastasis, which was reversed by the upregulation of miR-532-5p.

CONCLUSIONS

ACTA2-AS1 and miR-532-5p could act as biomarkers of TNBC predicting the progression and prognosis of patients. ACTA2-AS1 served as a tumor suppressor of TNBC which was mediated by miR-532-5p.

摘要

背景

ACTA2-AS1 和 miR-532-5p 的失调及其在各种癌症中的功能已被广泛报道。它们作为三阴性乳腺癌（TNBC）生物标志物的潜力尚不清楚。本研究旨在评估 ACTA2-AS1 和 miR-532-5p 的功能及其作为 TNBC 生物标志物的潜力。

结果

从 119 名患者中收集了 TNBC 组织，通过 PCR 观察到 ACTA2-AS1 水平降低和 miR-532-5p 水平升高，且呈显著负相关（P<0.001）。ACTA2-AS1 和 miR-532-5p 均与 TNBC 患者的恶性发展和不良预后密切相关。此外，在 TNBC 细胞中，过表达 ACTA2-AS1 被发现抑制细胞增殖和转移，而 miR-532-5p 的上调则逆转了这一作用。

结论

ACTA2-AS1 和 miR-532-5p 可作为预测 TNBC 患者进展和预后的生物标志物。ACTA2-AS1 作为 TNBC 的肿瘤抑制因子，其作用是由 miR-532-5p 介导的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13dd/9327331/4d4a4c665adf/12860_2022_432_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13dd/9327331/092d350a2374/12860_2022_432_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13dd/9327331/3e742bdf0e88/12860_2022_432_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13dd/9327331/0d248d9aace4/12860_2022_432_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13dd/9327331/343acfa7f372/12860_2022_432_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13dd/9327331/4d4a4c665adf/12860_2022_432_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13dd/9327331/092d350a2374/12860_2022_432_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13dd/9327331/3e742bdf0e88/12860_2022_432_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13dd/9327331/0d248d9aace4/12860_2022_432_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13dd/9327331/343acfa7f372/12860_2022_432_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13dd/9327331/4d4a4c665adf/12860_2022_432_Fig5_HTML.jpg

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