Jia Zixuan, Wang Ziqi, Pan Huixin, Zhang Jing, Wang Qinglu, Zhou Caixia, Liu Jun
Graduate School of Education, Shandong Sport University, Jinan, Shandong, China.
Eur J Med Res. 2024 Dec 31;29(1):637. doi: 10.1186/s40001-024-02176-w.
A high-fat diet and physical inactivity are key contributors to obesity, predisposing individuals to various chronic diseases, such as cardiovascular disease and diabetes, which involve multiple organs and tissues. To better understand the role of multi-organ interaction mechanisms in the rising incidence of obesity and its associated chronic conditions, treatment and prevention strategies are being extensively investigated. This review examines the signaling mechanisms between different tissues and organs, with a particular focus on the crosstalk between adipose tissue and the muscle, brain, liver, and heart, and potentially offers new strategies for the treatment and management of obesity and its complications.
高脂肪饮食和缺乏身体活动是导致肥胖的关键因素，使个体易患各种慢性疾病，如涉及多个器官和组织的心血管疾病和糖尿病。为了更好地理解多器官相互作用机制在肥胖发病率上升及其相关慢性病中的作用，人们正在广泛研究治疗和预防策略。这篇综述探讨了不同组织和器官之间的信号传导机制，特别关注脂肪组织与肌肉、大脑、肝脏和心脏之间的相互作用，并可能为肥胖及其并发症的治疗和管理提供新策略。
