全氟烷基和多氟烷基物质与孕早期母体内甲状腺激素。
Perfluoroalkyl and polyfluroalkyl substances and maternal thyroid hormones in early pregnancy.
机构信息
Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, 200092, China; School of Public Health, Shanghai Jiao Tong University, Shanghai, 200025, China.
Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, 200092, China.
出版信息
Environ Pollut. 2020 Sep;264:114557. doi: 10.1016/j.envpol.2020.114557. Epub 2020 Apr 30.
BACKGROUND
The development of the embryo and fetal brain depends on maternal transfer of thyroid hormones (THs) in early pregnancy. Perfluoroalkyl and polyfluoralkyl substances (PFAS) may disrupt maternal TH homeostasis in pregnancy, but findings from epidemiologic studies were inconsistent. We aimed to assess this relationship in early pregnancy in a large prospective cohort study.
METHODS
A total of 1885 pregnant women enrolled in the Shanghai Birth Cohort were used. Ten PFAS, free thyroxine (FT4), free triiodothyronine (FT3), thyroid stimulating hormone (TSH) and thyroid peroxidase antibody (TPOAb) were measured in maternal blood collected prior to 16 weeks of gestation. Multiple linear regression accompanied by restricted cubic spline was used to examine the association and the exposure-response relationship between each PFAS and TH in separate models. Possible effect modification by TPOAb status was also investigated.
RESULTS
Perfluorooctanoic acid [PFOA, β = 0.121, 95% confidence interval (CI): 0.015, 0.227] and perfluorohexane sulfonate (PFHxS, β = 0.123, 95% CI: 0.024, 0.222) were positively associated with FT4. Perfluorononanoic acid (PFNA, β = 0.179, 95% CI: 0.047, 0.311) and PFHxS (β = 0.197, 95% CI: 0.054, 0.339) were positively associated with FT3, while PFHxS was negatively associated with TSH (β = -0.115, 95%CI: 0.216, -0.014). TPOAb-positivity appeared to modify the associations between PFAS and THs. In TPOAb-positive women, several long-chain PFAS were positively associated with FT4 and/or FT3 and tended to be negatively associated with TSH.
CONCLUSIONS
Several long-chain PFAS were associated with disrupted TH homeostasis in Chinese pregnant women, especially among TPOAb-positive women.
背景
胚胎和胎儿大脑的发育依赖于妊娠早期母体甲状腺激素（THs）的传递。全氟烷基和多氟烷基物质（PFAS）可能会破坏妊娠期间母体 TH 的内稳态，但流行病学研究的结果并不一致。我们旨在通过一项大型前瞻性队列研究，在妊娠早期评估这种关系。
方法
共纳入 1885 名在上海出生队列中注册的孕妇。在妊娠 16 周之前采集母体血液，检测 10 种 PFAS、游离甲状腺素（FT4）、游离三碘甲状腺原氨酸（FT3）、促甲状腺激素（TSH）和甲状腺过氧化物酶抗体（TPOAb）。分别在单独的模型中使用多元线性回归和限制性立方样条来检验每种 PFAS 和 TH 之间的关联以及暴露-反应关系。还研究了 TPOAb 状态的可能效应修饰作用。
结果
全氟辛烷磺酸[PFOA，β=0.121，95%置信区间（CI）：0.015，0.227]和全氟己烷磺酸（PFHxS，β=0.123，95%CI：0.024，0.222）与 FT4 呈正相关。全氟壬酸（PFNA，β=0.179，95%CI：0.047，0.311）和 PFHxS（β=0.197，95%CI：0.054，0.339）与 FT3 呈正相关，而 PFHxS 与 TSH 呈负相关（β=-0.115，95%CI：0.216，-0.014）。TPOAb 阳性似乎改变了 PFAS 和 TH 之间的关联。在 TPOAb 阳性的女性中，几种长链 PFAS 与 FT4 和/或 FT3 呈正相关，且与 TSH 呈负相关。
结论
在中国孕妇中，几种长链 PFAS 与 TH 内稳态紊乱有关，尤其是在 TPOAb 阳性的女性中。
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