Faculty of Medicine, American University of Beirut, Beirut, Lebanon; Neuroscience Research Center, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon.
Department of Radiation Oncology, Henri Mondor University Hospital, AP-HP, and Henri Mondor Breast Cancer Center, INSERM U955 EQ 07, University of Paris-Est Créteil UPE4, Créteil, France.
Chin Clin Oncol. 2020 Jun;9(3):36. doi: 10.21037/cco.2020.04.02. Epub 2020 Apr 23.
Central nervous system (CNS) cancers are rare but deadly, with little data in the literature to describe its incidence in Middle East and North Africa (MENA) region. This study investigates the incidence-rates of these cancers MENA, determine Lebanon's current state in contrast, compare the incidence-rates of these cancers in Lebanon to other countries from several regions of the world, and discuss contributing risk factors.
CNS cancers data for the years 2005 to 2015 was collected from the National Cancer Registry of Lebanon and stratified by gender and age group. Age-specific and age-standardized incidence-rates were calculated and analyzed using Joinpoint regression. Age standardized incidence-rates to the world population [ASR(w)] for other countries were obtained from two online databases.
Lebanon ranked third and fourth in CNS cancers incidence in MENA region for males and females, respectively. However, Lebanon had low incidence when compared to other regions of the world. CNS cancers ASR(w) showed a non-significantly increasing trend over the period studied for Lebanese males and females. Incidence-rate increased with age in both sexes and the average age of incidence was around 44 years.
Lebanon has relatively high incidence of CNS cancer in both sexes when compared to other MENA countries. CNS cancers incidence-rate is on the rise and children younger than 9 years as well as adults above 30 years are remarkably burdened by these diseases. Several risk factors, particularly ionizing radiation and pesticide exposure play a role in increased CNS cancers incidence among the Lebanese population.
中枢神经系统（CNS）癌症较为罕见但却致命，目前文献中仅有少量数据可描述中东和北非（MENA）地区的此类癌症发病率。本研究旨在调查 MENA 地区 CNS 癌症的发病率，确定黎巴嫩目前的状况，比较黎巴嫩与世界其他地区的这些癌症的发病率，并讨论致病风险因素。
从黎巴嫩国家癌症登记处收集了 2005 年至 2015 年的 CNS 癌症数据，并按性别和年龄组进行分层。使用 Joinpoint 回归计算和分析了年龄特异性和年龄标准化发病率。从两个在线数据库中获得了其他国家的人口标准化发病率（ASR(w)）。
黎巴嫩男性和女性 CNS 癌症的发病率在 MENA 地区分别排名第三和第四。然而，与世界其他地区相比，黎巴嫩的发病率较低。黎巴嫩男性和女性的 CNS 癌症 ASR(w)在研究期间呈非显著上升趋势。两性的发病率均随年龄增长而增加，发病的平均年龄约为 44 岁。
与其他 MENA 国家相比，黎巴嫩两性的 CNS 癌症发病率相对较高。CNS 癌症的发病率呈上升趋势，9 岁以下儿童和 30 岁以上成年人受到这些疾病的严重影响。一些风险因素，特别是电离辐射和农药暴露，在黎巴嫩人群中 CNS 癌症发病率的增加中起作用。
