de Oliveira Letícia Lima, Bergmann Anke, Thuler Luiz Claudio Santos
Federal University of Rio de Janeiro State (UNIRIO), Rua Mariz e Barros, 775-Maracanã/ZIPCODE 20270-004, Rio de Janeiro, RJ, Brazil.
Brazilian National Cancer Institute (INCA), Rua André Cavalcanti, 37/2nd floor-Centro/ZIPCODE 20231-050, Rio de Janeiro, RJ, Brazil.
Neurooncol Pract. 2022 Aug 18;10(1):34-40. doi: 10.1093/nop/npac063. eCollection 2023 Feb.
In Brazil, 5870 new cases of malignant central nervous system tumors (MCNST) were estimated for men and 5220 for women for each year of the 2020-2022 triennium. The objective of this study was to analyze incidence rate trends and compare demographic characteristics of new MCNST cases according to tumor topographies in Brazil from 2000 to 2015.
This study comprises an analytical cross-sectional assessment of secondary databases extracted from the Brazilian National Cancer Institute (INCA) website. Data comprised new neoplasm cases of meninges (C70), brain (C71), spinal cord, cranial nerves, and other central nervous system parts (C72) retrieved from 23 population-based cancer registries. A descriptive analysis was performed. Crude and age-adjusted incidence rates were calculated. Linear trends were calculated using a linear least squares regression for adjusted incidence rates versus time.
A total of 24 986 new MCNST cases were recorded. The main topography was the brain (91.5%). Except for meninges tumors, where 62.4% of the cases were observed in women, MCNST cases were more frequent among men concerning the other evaluated topographies. All 3 topographies occurred predominantly in adult patients aged from 40- to 64-year-old. Between 2000 and 2015, incidence rates ranged from 5.12 to 4.95 (a 1.4% increase of per year; 95% CI -4.0 to 6.8; = .584) in men and from 4.35 to 3.61 (a 3.1% increase per year; 95% CI -1.7 to 8.0; = .189).
The most frequent topography was the brain. Incidence rates of MCNST remained relatively stable over time in both sexes.
在巴西，估计在2020 - 2022三年期的每年中，男性有5870例恶性中枢神经系统肿瘤（MCNST）新发病例，女性有5220例。本研究的目的是分析2000年至2015年巴西新MCNST病例的发病率趋势，并根据肿瘤部位比较其人口统计学特征。
本研究包括对从巴西国家癌症研究所（INCA）网站提取的二级数据库进行分析性横断面评估。数据包括从23个基于人群的癌症登记处检索到的脑膜（C70）、脑（C71）、脊髓、颅神经和其他中枢神经系统部位（C72）的新肿瘤病例。进行了描述性分析。计算了粗发病率和年龄调整发病率。使用线性最小二乘法回归计算调整发病率随时间的线性趋势。
共记录了24986例新的MCNST病例。主要部位是脑（91.5%）。除脑膜肿瘤外，62.4%的脑膜肿瘤病例见于女性，在其他评估部位，MCNST病例在男性中更为常见。所有3个部位主要发生在40至64岁的成年患者中。2000年至2015年期间，男性发病率从5.12降至4.95（每年增加1.4%；95%CI -4.0至6.8；P = 0.584），女性发病率从4.35降至3.61（每年增加3.1%；95%CI -1.7至8.0；P = 0.189）。
最常见的部位是脑。MCNST的发病率在两性中随时间保持相对稳定。
