探讨低剂量组织型纤溶酶原激活物对微泡介导正向可视血管内溶栓的影响。
Examining the Influence of Low-Dose Tissue Plasminogen Activator on Microbubble-Mediated Forward-Viewing Intravascular Sonothrombolysis.
机构信息
Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina, USA; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina, USA.
Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina, USA.
出版信息
Ultrasound Med Biol. 2020 Jul;46(7):1698-1706. doi: 10.1016/j.ultrasmedbio.2020.03.012. Epub 2020 May 7.
Previous work revealed that a forward-viewing intravascular (FVI) transducer can be used for microbubble (MB)-mediated sonothrombolysis and that the clot lysis was dependent on MB concentration. This study examined the effects of combining tissue plasminogen activator (tPA) with MB-mediated FVI sonothrombolysis. In vitro clot lysis and passive cavitation experiments were conducted to study the effect of low-dose tPA in FVI sonothrombolysis with varying MB concentrations. Enhanced FVI sonothrombolysis was observed in cases in which ultrasound (US) was combined with tPA or MBs compared with control, tPA alone or US alone. The lysis rate of US + tPA + MBs was improved by up to 130%, 31% and 8% for MB concentrations of 106, 107 and 108 MBs/mL, respectively, compared with MBs + US alone. Changes in stable and inertial cavitation doses were observed, corresponding to changes in clot lysis in MB-mediated FVI sonothrombolysis with and without tPA.
先前的工作表明，前向视血管内（FVI）换能器可用于微泡（MB）介导的声溶栓治疗，且血栓溶解依赖于 MB 浓度。本研究探讨了组织型纤溶酶原激活剂（tPA）与 MB 介导的 FVI 声溶栓联合应用的效果。通过体外血栓溶解和被动空化实验，研究了低剂量 tPA 在不同 MB 浓度下 FVI 声溶栓中的作用。与单独使用 tPA 或 US 相比，在联合 US、tPA 或 MB 的情况下，增强了 FVI 声溶栓效果。与单独使用 MB+US 相比，对于 MB 浓度为 106、107 和 108 MB/mL 的情况，US+tPA+MBs 的溶解率分别提高了 130%、31%和 8%。在有无 tPA 的 MB 介导的 FVI 声溶栓中，观察到稳定和惯性空化剂量的变化，这与血栓溶解的变化相对应。
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