用于 sonothrombolysis 的前向观察血管换能器的安全性评估：一项离体和在体研究。
Safety Evaluation of a Forward-Viewing Intravascular Transducer for Sonothrombolysis: An in Vitro and ex Vivo Study.
机构信息
Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina, USA; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina, USA.
Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina, USA.
出版信息
Ultrasound Med Biol. 2021 Nov;47(11):3231-3239. doi: 10.1016/j.ultrasmedbio.2021.07.018. Epub 2021 Aug 23.
Abstract
Recent in vitro work has revealed that a forward-viewing intravascular (FVI) transducer has sonothrombolysis applications. However, the safety of this device has yet to be evaluated. In this study, we evaluated the safety of this device in terms of tissue heating, vessel damage and particle debris size during sonothrombolysis using microbubbles or nanodroplets with tissue plasminogen activator, in both retracted and unretracted blood clots. The in vitro and ex vivo sonothrombolysis tests using FVI transducers revealed a temperature rise of less than 1°C, no vessel damage as assessed by histology and no downstream clot particles >500 µm. These in vitro and ex vivo results indicate that the FVI transducer poses minimal risk for sonothrombolysis applications and should be further evaluated in animal models.
摘要
最近的体外研究表明，前视血管内（FVI）换能器具有 sonothrombolysis 应用。然而，该设备的安全性尚未得到评估。在这项研究中，我们评估了该设备在回缩和未回缩血栓中使用微泡或纳米液滴与组织纤溶酶原激活剂进行 sonothrombolysis 时的组织加热、血管损伤和颗粒碎片大小方面的安全性。使用 FVI 换能器进行的体外和离体 sonothrombolysis 测试显示，温度升高低于 1°C，组织学评估无血管损伤，下游血栓颗粒 >500 µm。这些体外和离体结果表明，FVI 换能器在 sonothrombolysis 应用中风险最小，应在动物模型中进一步评估。
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