Sezione di Gastroenterologia e Epatologia, PROMISE, Università di Palermo, Italia.
Sezione di Gastroenterologia e Epatologia, PROMISE, Università di Palermo, Italia.
Gastroenterol Clin North Am. 2020 Jun;49(2):347-360. doi: 10.1016/j.gtc.2020.01.012. Epub 2020 Mar 29.
Hepatits C virus (HCV) infection has been largely associated with extrahepatic comorbidities such as diseases related to dysregulation of the immune system, neuropsychiatric disorders, and cardiometabolic alterations. These clinical consequences, together with experimental evidence, suggest a potential (in)direct effect of HCV, contributing to the pathogenesis of these diseases. Various studies have reported a positive effect of viral eradication on occurrence and outcomes of extrahepatic diseases. These observations and the availability of safe and effective direct antiviral agents further underline the need to search for virological eradication in all infected individuals independent of the severity of the liver disease.
丙型肝炎病毒 (HCV) 感染与肝外合并症密切相关，如与免疫系统失调、神经精神疾病和心血管代谢改变相关的疾病。这些临床后果以及实验证据表明 HCV 可能具有潜在的（直接或间接）作用，有助于这些疾病的发病机制。多项研究报告称，病毒清除对肝外疾病的发生和结局有积极影响。这些观察结果以及安全有效的直接抗病毒药物的出现进一步强调了需要在所有感染个体中寻找病毒学清除，而不论肝脏疾病的严重程度如何。
