Liver Unit, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK.
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
BMJ Open Gastroenterol. 2021 Mar;8(1). doi: 10.1136/bmjgast-2020-000591.
Hepatitis C virus (HCV) infection is associated with an increased risk of cardiovascular disease (CVD) and reduced health-related quality of life (HRQoL). Although physical activity (PA)/exercise has been shown to reduce CVD risk and improve HRQoL in patients with liver disease, there is limited data in HCV. We aimed to explore the association between PA/exercise levels, CVD risk and HRQoL in patients with HCV and assess individuals' attitudes to PA/exercise.
Cross-sectional observational study recruiting consecutive patients with HCV from viral hepatitis clinics. Data were collected on CVD risk factors, anthropometry, HRQoL and the Exercise Benefits and Barriers Scale (EBBS).
86 patients were recruited (71% men, 94% white, age 52±13 years); 49% of the cohort self-reported to be currently active. Although HRQoL was reduced across the cohort, patients that were regularly 'active' reported significantly higher HRQoL scores across Short-Form 36v2 domains compared with their inactive counterparts (p<0.05). Metabolic and cardiovascular characteristics were no different between groups stratified by PA/exercise status (p>0.05). EBBS scores were similar in the 'active' versus 'inactive' groups, however, patients categorised as 'active' scored significantly higher on the psychological outlook and social interaction subscales (p<0.05) than those that were 'inactive'. There were significant associations between EBBS scores and HRQoL (p<0.05).
PA/exercise is associated with increased HRQoL in patients with HCV irrespective of clinical parameters. Addressing specific motivators/barriers to exercise for patients will be key to designing effective PA/exercise interventions in this patient population to ensure maximum uptake and adherence.
丙型肝炎病毒（HCV）感染与心血管疾病（CVD）风险增加和健康相关生活质量（HRQoL）降低有关。尽管已经证明体力活动（PA）/运动可以降低肝病患者的 CVD 风险并改善 HRQoL，但在 HCV 患者中数据有限。我们旨在探讨 HCV 患者 PA/运动水平与 CVD 风险和 HRQoL 之间的关系，并评估个体对 PA/运动的态度。
从病毒性肝炎诊所招募连续 HCV 患者的横断面观察性研究。收集 CVD 危险因素、人体测量学、HRQoL 和锻炼益处和障碍量表（EBBS）的数据。
共招募了 86 名患者（71%为男性，94%为白人，年龄 52±13 岁）；该队列中有 49%的人报告目前活跃。尽管整个队列的 HRQoL 都有所降低，但经常“活跃”的患者在 SF-36v2 各领域的 HRQoL 评分明显高于不活跃的患者（p<0.05）。根据 PA/运动状态分层，代谢和心血管特征在两组之间无差异（p>0.05）。在“活跃”组与“不活跃”组之间，EBBS 评分相似，但归类为“活跃”的患者在心理展望和社会互动子量表上的得分明显高于不活跃的患者（p<0.05）。EBBS 评分与 HRQoL 之间存在显著相关性（p<0.05）。
PA/运动与 HCV 患者的 HRQoL 增加有关，无论临床参数如何。针对患者的具体运动动机/障碍进行干预将是为该患者人群设计有效 PA/运动干预措施的关键，以确保最大的参与度和依从性。
